Explainable PET-Based Habitat and Peritumoral Machine Learning Model for Predicting Progression-free Survival in Clinical Stage IA Pure-Solid Non-small Cell Lung Cancer: A Two-center Study.

Journal: Academic radiology
Published Date:

Abstract

RATIONALE AND OBJECTIVES: This study aimed to develop and validate machine learning (ML) models utilizing positron emission tomography (PET)-habitat of the tumor and its peritumoral microenvironment to predict progression-free survival (PFS) in patients with clinical stage IA pure-solid non-small cell lung cancer (NSCLC).

Authors

  • Bei-Hui Xue
    Division of Pulmonary Medicine, the First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang, China (B.H.X., J.P.L.); Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (B.H.X., S.L.C., J.G.X., X.W.Z.).
  • Shuang-Li Chen
    Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (B.H.X., S.L.C., J.G.X., X.W.Z.).
  • Jun-Ping Lan
    Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (B.H.X., S.L.C., J.G.X., X.W.Z.).
  • Li-Li Wang
    Department of Radiology, Wenzhou Central Hospital, China (L.L.W.).
  • Jia-Geng Xie
    Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (B.H.X., S.L.C., J.G.X., X.W.Z.).
  • Xiang-Wu Zheng
    Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (B.H.X., S.L.C., J.G.X., X.W.Z.).
  • Liang-Xing Wang
    Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Key Laboratory of Interdiscipline and Translational Medicine, Wenzhou Key Laboratory of Heart and Lung, Wenzhou, China (L.X.W.).
  • Kun Tang
    Engineering Research Center of Text Computing & Cognitive Intelligence, Ministry of Education, Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province, State Key Laboratory of Public Big Data, College of Computer Science and Technology, Guizhou University, Guiyang, China.