Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.

Journal: Journal of affective disorders
Published Date:

Abstract

BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic stress, molecular changes, and depression severity.

Authors

  • Yanlin Tao
    Shanghai Key Laboratory of Compound Chinese Medicines, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, the MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; Institute for Translational Brain Research, Fudan University, Shanghai, PR China.
  • Zikang Li
    Department of Electrical Engineering, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, P.R.China.
  • Jinfeng Yuan
    State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, China.
  • Huizhen Wang
    Department of Rehabilitation Medicine, The 8th Medical Center of Chinese PLA General Hospital, Beijing,100091, China. whz01062020@163.com.
  • Yi He
    National Institutes for Food and Drug Control, 2 Tiantan Xili, Beijing 100050, China.
  • Hui Wu
    China Medical University College of Health Management, Shenyang 110122, Liaoning Province, China.
  • Jian Yang
    Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
  • Hailian Shi
    Shanghai Key Laboratory of Compound Chinese Medicines, the Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, the MOE Innovation Centre for Basic Medicine Research on Qi-Blood TCM Theories, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
  • Gang Wang
    National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
  • Xiaojun Wu
    Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.
  • Fei Huang
    Alibaba Damo Academy, 969 West Wen Yi Road, Yu Hang District, Hangzhou, Zhejiang, China.