Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.

Journal: Science robotics
PMID: 33022593

Abstract

Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to date is only in its proof-of-concept stage. To use the microrobot in a clinical stage, biocompatibility and biodegradation materials should be considered in the microrobot, and its efficacy needs to be verified using an in vivo model. In this study, we propose a human adipose-derived MSC-based medical microrobot system for knee cartilage regeneration and present an in vivo trial to verify the efficacy of the microrobot using the cartilage defect model. The microrobot system consists of a microrobot body capable of supporting MSCs, an electromagnetic actuation system for three-dimensional targeting of the microrobot, and a magnet for fixation of the microrobot to the damaged cartilage. Each component was designed and fabricated considering the accessibility of the patient and medical staff, as well as clinical safety. The efficacy of the microrobot system was then assessed in the cartilage defect model of rabbit knee with the aim to obtain clinical trial approval.

Authors

  • Gwangjun Go
    School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea.
  • Sin-Gu Jeong
    Biot Korea Inc., 43-26 Chemdangwagi-ro 208 Beon-gil, Gwangju 61001, Korea.
  • Ami Yoo
    Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.
  • Jiwon Han
    School of Mechanical Engineering, Chonnam National University, Gwangju, Korea.
  • Byungjeon Kang
    Center for Micro-BioRobotics, Istituto Italiano di Tecnologia, Pontedera, Italy.
  • Seokjae Kim
    Korea Institute of Medical Microrobotics (KIMIRo), 43-26 Cheomdangwagi-ro, Buk-gu, Gwangju 61011, Korea.
  • Kim Tien Nguyen
  • Zhen Jin
    Korea Institute of Medical Microrobotics , 43-26 Cheomdangwagi-ro , Buk-gu, Gwangju 61011 , Republic of Korea.
  • Chang-Sei Kim
  • Yu Ri Seo
    Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.
  • Ju Yeon Kang
    Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.
  • Ju Yong Na
    Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.
  • Eun Kyoo Song
    Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea.
  • Yongyeon Jeong
    Department of Radiology, Chonnam National University Hwasun Hospital, 322 Hwasun-eup, Seoyang-ro, Hwasun 58128, Korea.
  • Jong Keun Seon
    Center for Joint Disease, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun 58128, Korea. seonbell@jnu.ac.kr jop@kimiro.re.kr eunpyochoi@jnu.ac.kr.
  • Jong-Oh Park
    School of Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea. Electronic address: jop@jnu.ac.kr.
  • Eunpyo Choi

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