AIMC Topic: Mesenchymal Stem Cell Transplantation

Clear Filters Showing 1 to 9 of 9 articles

Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.

Nature communications May 15, 2025
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
Mice Nanoparticles Liver Cirrhosis Disease Models, Animal Humans Mesenchymal Stem Cells Animals Endothelial Cells Mice, Inbred C57BL Nucleic Acids Male Mesenchymal Stem Cell Transplantation Liver MicroRNAs
View on PubMed DOI

Magnetic soft microrobots for erectile dysfunction therapy.

Proceedings of the National Academy of Sciences of the United States of America Nov 18, 2024
Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpu...
Robotics Rats Magnetite Nanoparticles Penis Rats, Sprague-Dawley Mesenchymal Stem Cell Transplantation Dogs Mesenchymal Stem Cells Disease Models, Animal Humans Erectile Dysfunction Animals Male
View on PubMed DOI

Machine learning reveals the rules governing the efficacy of mesenchymal stromal cells in septic preclinical models.

Stem cell research & therapy Sep 11, 2024
BACKGROUND: Mesenchymal Stromal Cells (MSCs) are the preferred candidates for therapeutics as they possess multi-directional differentiation potential, exhibit potent immunomodulatory activity, are anti-inflammatory, and can function like antimicrobi...
Animals Sepsis Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation Humans Machine Learning
View on PubMed DOI

Unlocking the full potential of mesenchymal stromal cell therapy for osteoarthritis through machine learning-based in silico trials.

Cytotherapy May 19, 2024
Despite the potential of mesenchymal stromal cells (MSCs) in osteoarthritis (OA) treatment, the challenge lies in addressing their therapeutic inconsistency. Clinical trials revealed significantly varied therapeutic outcomes among patients receiving ...
Osteoarthritis Mesenchymal Stem Cells Clinical Trials as Topic Female Male Treatment Outcome Mesenchymal Stem Cell Transplantation Algorithms Computer Simulation Humans Machine Learning
View on PubMed DOI

Implementation of transfer learning for the segmentation of human mesenchymal stem cells-A validation study.

Tissue & cell Jun 29, 2023
INTRODUCTION: Stem cell therapy has been gaining interest in the regeneration rather than repair of lost human tissues. However, the manual analysis of stem cells prior to implantation is a cumbersome task that can be automated to improve the efficie...
Data Curation Cell Tracking Mesenchymal Stem Cell Transplantation Deep Learning Mesenchymal Stem Cells Datasets as Topic Algorithms
View on PubMed DOI

Machine learning to predict mesenchymal stem cell efficacy for cartilage repair.

PLoS computational biology Oct 7, 2020
Inconsistent therapeutic efficacy of mesenchymal stem cells (MSCs) in regenerative medicine has been documented in many clinical trials. Precise prediction on the therapeutic outcome of a MSC therapy based on the patient's conditions would provide va...
Humans Machine Learning Animals Rats Models, Biological Swine Computational Biology Tissue Engineering Rabbits Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Cartilage
View on PubMed DOI

Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.

Cytokine Jul 1, 2025
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...
Rats Inflammation Rats, Sprague-Dawley Male Mesenchymal Stem Cell Transplantation Humans Mesenchymal Stem Cells Gene Expression Profiling Female Spinal Cord Injuries Transcriptome Animals
View on PubMed DOI

Efficacy of robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell transplantation for osteonecrosis of the femoral head.

European review for medical and pharmacological sciences Jun 1, 2022
OBJECTIVE: The aim of this paper was to evaluate the effects of robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation for early-stage osteonecrosis of the femoral head (ONFH).
Mesenchymal Stem Cell Transplantation Decompression Retrospective Studies Robotics Immunologic Factors Umbilical Cord Humans Femur Head Necrosis Osteonecrosis
View on PubMed DOI

Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.

Science robotics Jan 22, 2020
Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to d...
Cell- and Tissue-Based Therapy Robotics Mesenchymal Stem Cell Transplantation Cell Differentiation Polylactic Acid-Polyglycolic Acid Copolymer Equipment Design Electromagnetic Phenomena Humans Mesenchymal Stem Cells Cells, Cultured Microscopy, Electron, Scanning Cell Adhesion Robotic Surgical Procedures Regeneration Animals Tissue Scaffolds Cartilage, Articular Knee Joint Cell Proliferation Rabbits
View on PubMed DOI
Popular Topics
Recent Journals