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Mesenchymal Stem Cell Transplantation

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Machine learning to predict mesenchymal stem cell efficacy for cartilage repair.

PLoS computational biology
Inconsistent therapeutic efficacy of mesenchymal stem cells (MSCs) in regenerative medicine has been documented in many clinical trials. Precise prediction on the therapeutic outcome of a MSC therapy based on the patient's conditions would provide va...

Efficacy of robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell transplantation for osteonecrosis of the femoral head.

European review for medical and pharmacological sciences
OBJECTIVE: The aim of this paper was to evaluate the effects of robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation for early-stage osteonecrosis of the femoral head (ONFH).

Implementation of transfer learning for the segmentation of human mesenchymal stem cells-A validation study.

Tissue & cell
INTRODUCTION: Stem cell therapy has been gaining interest in the regeneration rather than repair of lost human tissues. However, the manual analysis of stem cells prior to implantation is a cumbersome task that can be automated to improve the efficie...

Unlocking the full potential of mesenchymal stromal cell therapy for osteoarthritis through machine learning-based in silico trials.

Cytotherapy
Despite the potential of mesenchymal stromal cells (MSCs) in osteoarthritis (OA) treatment, the challenge lies in addressing their therapeutic inconsistency. Clinical trials revealed significantly varied therapeutic outcomes among patients receiving ...

Machine learning reveals the rules governing the efficacy of mesenchymal stromal cells in septic preclinical models.

Stem cell research & therapy
BACKGROUND: Mesenchymal Stromal Cells (MSCs) are the preferred candidates for therapeutics as they possess multi-directional differentiation potential, exhibit potent immunomodulatory activity, are anti-inflammatory, and can function like antimicrobi...

Magnetic soft microrobots for erectile dysfunction therapy.

Proceedings of the National Academy of Sciences of the United States of America
Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpu...