AIMC Topic: Polylactic Acid-Polyglycolic Acid Copolymer

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Predicting PLGA nanoparticle size and zeta potential in synthesis for application of drug delivery via machine learning analysis.

Scientific reports Jul 1, 2025
This study employed multiple machine learning (ML) methods to model and predict key attributes of PLGA nanoparticles, specifically particle size and zeta potential. The predictions were based on input variables, including PLGA polymer type, PLGA conc...
Nanoparticles Particle Size Polylactic Acid-Polyglycolic Acid Copolymer Machine Learning Drug Delivery Systems
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iPSC-RPE patch restores photoreceptors and regenerates choriocapillaris in a pig retinal degeneration model.

JCI insight May 22, 2025
Dry age-related macular degeneration (AMD) is a leading cause of untreatable vision loss. In advanced cases, retinal pigment epithelium (RPE) cell loss occurs alongside photoreceptor and choriocapillaris degeneration. We hypothesized that an RPE-patc...
Animals Swine Tomography, Optical Coherence Regeneration Tissue Scaffolds Disease Models, Animal Choroid Polylactic Acid-Polyglycolic Acid Copolymer Retinal Pigment Epithelium Retinal Degeneration Induced Pluripotent Stem Cells
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PLGA-based long-acting injectable (LAI) formulations.

Journal of controlled release : official journal of the Controlled Release Society Apr 21, 2025
Long-acting injectable (LAI) formulations, which deliver drugs over weeks or months, have been in use for more than three decades. Most clinically approved LAI products are formulated using poly(lactide-co-glycolide) (PLGA) polymers. Historically, th...
Humans Artificial Intelligence Injections Drug Liberation Delayed-Action Preparations Animals Drug Compounding Polylactic Acid-Polyglycolic Acid Copolymer Chemistry, Pharmaceutical
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Utilization of machine learning approach for production of optimized PLGA nanoparticles for drug delivery applications.

Scientific reports Mar 14, 2025
This study investigates utilization of machine learning for the regression task of predicting the size of PLGA (Poly lactic-co-glycolic acid) nanoparticles. Various inputs including category and numeric were considered for building the model to predi...
Particle Size Polylactic Acid-Polyglycolic Acid Copolymer Machine Learning Algorithms Drug Delivery Systems Nanoparticles
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Machine learning integrated with in vitro experiments for study of drug release from PLGA nanoparticles.

Scientific reports Feb 4, 2025
This paper investigates delivery of encapsulated drug from poly lactic-co-glycolic micro-/nano-particles. Experimental data collected from about 50 papers are analyzed by machine learning algorithms including linear regression, principal component an...
Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Drug Liberation Lactic Acid Particle Size Drug Carriers Machine Learning Hydrogen-Ion Concentration Principal Component Analysis Nanoparticles Neural Networks, Computer Solubility
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Optimising the production of PLGA nanoparticles by combining design of experiment and machine learning.

International journal of pharmaceutics Nov 2, 2024
Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer in drug delivery and nanoparticle (NP) formulation due to its controlled drug release properties and safety profiles. Among the methods available for NP production, nanopreci...
Research Design Nanoparticles Drug Carriers Chemistry, Pharmaceutical Particle Size Machine Learning Polylactic Acid-Polyglycolic Acid Copolymer
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Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo.

Science robotics Jan 22, 2020
Targeted cell delivery by a magnetically actuated microrobot with a porous structure is a promising technique to enhance the low targeting efficiency of mesenchymal stem cell (MSC) in tissue regeneration. However, the relevant research performed to d...
Polylactic Acid-Polyglycolic Acid Copolymer Cell- and Tissue-Based Therapy Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Regeneration Robotics Animals Equipment Design Electromagnetic Phenomena Knee Joint Cell Differentiation Cell Proliferation Humans Robotic Surgical Procedures Cell Adhesion Rabbits Microscopy, Electron, Scanning Cells, Cultured Cartilage, Articular Tissue Scaffolds
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