IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
The virus poses a longstanding and enduring danger to various forms of life. Despite the ongoing endeavors to combat viral diseases, there exists a necessity to explore and develop novel therapeutic options. Antiviral peptides are bioactive molecules...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
One of the primary tasks in the early stages of data mining involves the identification of entities from biomedical corpora. Traditional approaches relying on robust feature engineering face challenges when learning from available (un-)annotated data...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
This review article delves deeply into the various machine learning (ML) methods and algorithms employed in discerning protein functions. Each method discussed is assessed for its efficacy, limitations, potential improvements, and future prospects. W...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Deep learning approaches, such as convolution neural networks (CNNs) and deep recurrent neural networks (RNNs), have been the backbone for predicting protein function, with promising state-of-the-art (SOTA) results. RNNs with an in-built ability (i) ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Microarray data provide lots of information regarding gene expression levels. Due to the large amount of such data, their analysis requires sufficient computational methods for identifying and analyzing gene regulation networks; however, researchers ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Brain functional network (BFN) analysis has become a popular method for identifying neurological diseases at their early stages and revealing sensitive biomarkers related to these diseases. Due to the fact that BFN is a graph with complex structure, ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
DNA N-methyladenine (6mA) is an important epigenetic modification that plays a vital role in various cellular processes. Accurate identification of the 6mA sites is fundamental to elucidate the biological functions and mechanisms of modification. How...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Graph neural networks have drawn increasing attention and achieved remarkable progress recently due to their potential applications for a large amount of irregular data. It is a natural way to represent protein as a graph. In this work, we focus on p...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Circular RNAs (circRNAs) play a significant role in cancer development and therapy resistance. There is substantial evidence indicating that the expression of circRNAs affects the sensitivity of cells to drugs. Identifying circRNAs-drug sensitivity a...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Biomedical relation extraction aims to identify underlying relationships among entities, such as gene associations and drug interactions, within biomedical texts. Despite advancements in relation extraction in general knowledge domains, the scarcity ...