AIMC Topic: Abortion, Habitual

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Discovery of protein lactylation-associated biomarkers and their potential pathogenic mechanisms in recurrent spontaneous abortion.

International journal of biological macromolecules Sep 1, 2025
Protein lactylation plays a critical regulatory role in various human diseases; however, its function in recurrent spontaneous abortion (RSA) remains unclear. In this study, we integrated scRNA-seq (GSE214607), bulk RNA-seq (GSE26787 and GSE165004) d...
Humans Biomarkers Pregnancy Female Cell Proliferation Signal Transduction S100 Proteins Apoptosis Gene Expression Regulation Abortion, Habitual Trophoblasts
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Upregulation of immune genes in the proliferative phase endometrium enables classification into women with recurrent pregnancy loss versus controls.

Human reproduction (Oxford, England) Jun 1, 2025
STUDY QUESTION: Does the transcriptome of preconceptional endometrium in the proliferative phase show a specific profile in women with recurrent pregnancy loss (RPL)?
Humans Pregnancy Female Young Adult Adult Gene Expression Profiling Transcriptome Case-Control Studies Endometrium Up-Regulation Abortion, Habitual
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High throughput recurrent pregnancy loss screening: urine metabolic fingerprints LDI-MS and machine learning.

The Analyst May 12, 2025
Infertility is a significant challenge faced by many families worldwide, with recurrent pregnancy loss (RPL) being a prevalent cause of infertility among women. This condition causes immense emotional and physical distress for affected individuals an...
Humans Machine Learning Pregnancy Female Adult Metabolomics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization High-Throughput Screening Assays Abortion, Habitual
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