AIMC Topic: Acetylation

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Exploring acetylation-related gene markers in polycystic ovary syndrome: insights into pathogenesis and diagnostic potential using machine learning.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Nov 25, 2024
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a prevalent cause of menstrual irregularities and infertility in women, impacting quality of life. Despite advancements, current understanding of PCOS pathogenesis and treatment remains limited. This stu...
Genetic Markers Polycystic Ovary Syndrome Acetylation Humans Machine Learning Female
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Prediction of protein N-terminal acetylation modification sites based on CNN-BiLSTM-attention model.

Computers in biology and medicine Mar 21, 2024
N-terminal acetylation is one of the most common and important post-translational modifications (PTM) of eukaryotic proteins. PTM plays a crucial role in various cellular processes and disease pathogenesis. Thus, the accurate identification of N-term...
Proteins Databases, Protein Acetylation Humans Deep Learning Neural Networks, Computer Protein Processing, Post-Translational Algorithms
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Leveraging Protein Dynamics to Identify Functional Phosphorylation Sites using Deep Learning Models.

Journal of chemical information and modeling Jul 11, 2022
Accurate prediction of post-translational modifications (PTMs) is of great significance in understanding cellular processes, by modulating protein structure and dynamics. Nowadays, with the rapid growth of protein data at different "omics" levels, ma...
Phosphorylation Acetylation Deep Learning Protein Processing, Post-Translational Proteins
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Analysis and prediction of human acetylation using a cascade classifier based on support vector machine.

BMC bioinformatics Jun 17, 2019
BACKGROUND: Acetylation on lysine is a widespread post-translational modification which is reversible and plays a crucial role in some biological activities. To better understand the mechanism, it is necessary to identify acetylation sites in protein...
Protein Structure, Secondary Position-Specific Scoring Matrices Lysine Molecular Sequence Annotation Gene Ontology Amino Acid Sequence Acetylation Computational Biology Rats Support Vector Machine Humans Protein Processing, Post-Translational Animals Proteins Mice Databases, Protein
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A deep learning method to more accurately recall known lysine acetylation sites.

BMC bioinformatics Jan 23, 2019
BACKGROUND: Lysine acetylation in protein is one of the most important post-translational modifications (PTMs). It plays an important role in essential biological processes and is related to various diseases. To obtain a comprehensive understanding o...
Deep Learning Protein Processing, Post-Translational Acetylation Lysine
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Rapid LC-MS/MS quantification of cancer related acetylated polyamines in human biofluids.

Talanta Dec 26, 2018
Increased urinary acetylated polyamines (APs) are reported as cancer biomarkers in many studies. N,N-diacetylspermine has been proposed as a biomarker indicative of different cancers in urine and plasma. N-Acetylspermine has previously been found to ...
Acetylation Polyamines Chromatography, Liquid Humans Saliva Biomarkers, Tumor Tandem Mass Spectrometry
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Prediction and functional analysis of prokaryote lysine acetylation site by incorporating six types of features into Chou's general PseAAC.

Journal of theoretical biology Oct 23, 2018
Lysine acetylation is one of the most important types of protein post-translational modifications (PTM) that are widely involved in cellular regulatory processes. To fully understand the regulatory mechanism of acetylation, identification of acetylat...
Lysine Binding Sites Prokaryotic Cells Datasets as Topic Bacteria Species Specificity Protein Processing, Post-Translational Computational Biology Acetylation Bacterial Proteins Support Vector Machine
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Prediction of lysine propionylation sites using biased SVM and incorporating four different sequence features into Chou's PseAAC.

Journal of molecular graphics & modelling Jul 25, 2017
Lysine propionylation is an important and common protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of propionylation, it is important to identify propionylated substrates and their corresp...
Algorithms Protein Processing, Post-Translational Computational Biology Acetylation Reproducibility of Results Amino Acids Support Vector Machine Lysine Amino Acid Sequence Peptides Position-Specific Scoring Matrices
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TransPTM: a transformer-based model for non-histone acetylation site prediction.

Briefings in bioinformatics Mar 27, 2024
Protein acetylation is one of the extensively studied post-translational modifications (PTMs) due to its significant roles across a myriad of biological processes. Although many computational tools for acetylation site identification have been develo...
Humans Proteins Databases, Protein Acetylation Algorithms Neural Networks, Computer Computational Biology Software Protein Processing, Post-Translational
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Deep learning based prediction of reversible HAT/HDAC-specific lysine acetylation.

Briefings in bioinformatics Sep 25, 2020
Protein lysine acetylation regulation is an important molecular mechanism for regulating cellular processes and plays critical physiological and pathological roles in cancers and diseases. Although massive acetylation sites have been identified throu...
Acetylation Lysine Histone Deacetylases Internet Datasets as Topic Humans Neoplasms Deep Learning
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