AIMC Topic: Acetylation

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Prediction of lysine propionylation sites using biased SVM and incorporating four different sequence features into Chou's PseAAC.

Journal of molecular graphics & modelling Jul 25, 2017
Lysine propionylation is an important and common protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of propionylation, it is important to identify propionylated substrates and their corresp...
Algorithms Reproducibility of Results Peptides Computational Biology Support Vector Machine Protein Processing, Post-Translational Amino Acids Amino Acid Sequence Acetylation Lysine Position-Specific Scoring Matrices
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Downregulation of HDAC9 Alleviates Autophagy Dysfunction by Inducing Acetylation of ATG4B in Metabolic Dysfunction-Associated Steatotic Liver Disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Sep 15, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent hepatic metabolic disorder with a rising global incidence. Epigenetic modifications-such as methylation, acetylation, phosphorylation, and ubiquitination-play critical ro...
Humans Animals Male Mice Fatty Liver Mice, Inbred C57BL Liver Autophagy Down-Regulation Acetylation Repressor Proteins Cysteine Endopeptidases Histone Deacetylases Autophagy-Related Proteins
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TransPTM: a transformer-based model for non-histone acetylation site prediction.

Briefings in bioinformatics Mar 27, 2024
Protein acetylation is one of the extensively studied post-translational modifications (PTMs) due to its significant roles across a myriad of biological processes. Although many computational tools for acetylation site identification have been develo...
Humans Neural Networks, Computer Software Algorithms Computational Biology Protein Processing, Post-Translational Proteins Databases, Protein Acetylation
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Deep learning based prediction of reversible HAT/HDAC-specific lysine acetylation.

Briefings in bioinformatics Sep 25, 2020
Protein lysine acetylation regulation is an important molecular mechanism for regulating cellular processes and plays critical physiological and pathological roles in cancers and diseases. Although massive acetylation sites have been identified throu...
Humans Neoplasms Deep Learning Internet Datasets as Topic Acetylation Lysine Histone Deacetylases
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