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Action Potentials

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Visual explanations from spiking neural networks using inter-spike intervals.

Scientific reports
By emulating biological features in brain, Spiking Neural Networks (SNNs) offer an energy-efficient alternative to conventional deep learning. To make SNNs ubiquitous, a 'visual explanation' technique for analysing and explaining the internal spike b...

Universal Nonlinear Spiking Neural P Systems with Delays and Weights on Synapses.

Computational intelligence and neuroscience
The nonlinear spiking neural P systems (NSNP systems) are new types of computation models, in which the state of neurons is represented by real numbers, and nonlinear spiking rules handle the neuron's firing. In this work, in order to improve computi...

Constrained plasticity reserve as a natural way to control frequency and weights in spiking neural networks.

Neural networks : the official journal of the International Neural Network Society
Biological neurons have adaptive nature and perform complex computations involving the filtering of redundant information. However, most common neural cell models, including biologically plausible, such as Hodgkin-Huxley or Izhikevich, do not possess...

Dendritic normalisation improves learning in sparsely connected artificial neural networks.

PLoS computational biology
Artificial neural networks, taking inspiration from biological neurons, have become an invaluable tool for machine learning applications. Recent studies have developed techniques to effectively tune the connectivity of sparsely-connected artificial n...

A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging.

Nature neuroscience
Inference of action potentials ('spikes') from neuronal calcium signals is complicated by the scarcity of simultaneous measurements of action potentials and calcium signals ('ground truth'). In this study, we compiled a large, diverse ground truth da...

Artificial Intelligence-Enabled ECG to Identify Silent Atrial Fibrillation in Embolic Stroke of Unknown Source.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
OBJECTIVES: Embolic strokes of unknown source (ESUS) are common and often suspected to be caused by unrecognized paroxysmal atrial fibrillation (AF). An AI-enabled ECG (AI-ECG) during sinus rhythm has been shown to identify patients with unrecognized...

A simple parametric representation of the Hodgkin-Huxley model.

PloS one
The Hodgkin-Huxley model, decades after its first presentation, is still a reference model in neuroscience as it has successfully reproduced the electrophysiological activity of many organisms. The primary signal in the model represents the membrane ...

Partial information decomposition reveals that synergistic neural integration is greater downstream of recurrent information flow in organotypic cortical cultures.

PLoS computational biology
The directionality of network information flow dictates how networks process information. A central component of information processing in both biological and artificial neural networks is their ability to perform synergistic integration-a type of co...

Online Learning and Memory of Neural Trajectory Replays for Prefrontal Persistent and Dynamic Representations in the Irregular Asynchronous State.

Frontiers in neural circuits
In the prefrontal cortex (PFC), higher-order cognitive functions and adaptive flexible behaviors rely on continuous dynamical sequences of spiking activity that constitute neural trajectories in the state space of activity. Neural trajectories subser...

A deep learning algorithm to translate and classify cardiac electrophysiology.

eLife
The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been a critical in vitro advance in the study of patient-specific physiology, pathophysiology, and pharmacology. We designed a new deep learning multitask network ...