Journal of chemical information and modeling
Dec 19, 2022
Intrinsically disordered proteins (IDPs) are proteins without a fixed three-dimensional (3D) structure under physiological conditions and are associated with Parkinson's disease, Alzheimer's disease, cancer, cardiovascular disease, amyloidosis, diabe...
BACKGROUND: Alzheimer's disease has become one of the most common neurodegenerative diseases worldwide, which seriously affects the health of the elderly. Early detection and intervention are the most effective prevention methods currently. Compared ...
Computer methods and programs in biomedicine
Nov 30, 2022
BACKGROUND AND OBJECTIVE: Mild cognitive impairment (MCI) is a transitional state between normal aging and Alzheimer's disease (AD), and accurately predicting the progression trend of MCI is critical to the early prevention and treatment of AD. Brain...
Deep neural networks are increasingly used for neurological disease classification by MRI, but the networks' decisions are not easily interpretable by humans. Heat mapping by deep Taylor decomposition revealed that (potentially misleading) image feat...
Exploring individual brain atrophy patterns is of great value in precision medicine for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, the current individual brain atrophy detection models are deficient. Here, we proposed a fr...
Deep neural networks have been successfully applied to generate predictive patterns from medical and diagnostic data. This paper presents an approach for assessing persons with Alzheimer's disease (AD) mild cognitive impairment (MCI), compared with n...
Physical and engineering sciences in medicine
Nov 10, 2022
The study aims to implement a convolutional neural network framework that uses the 18F-FDG PET modality of brain imaging to detect multiple stages of dementia, including Early Mild Cognitive Impairment (EMCI) and Late Mild Cognitive Impairment (LMCI)...
Alzheimer's disease is a neurodegenerative condition that gradually impairs cognitive abilities. Recently, various neuroimaging modalities and machine learning methods have surfaced to diagnose Alzheimer's disease. Resting-state fMRI is a neuroimagin...
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Oct 27, 2022
Alzheimer's disease (AD), a neurodegenerative disorder characterized by progressive cognitive decline, is generally prevalent in elderly people with significant disability and mortality. There is no effective treatment for AD currently, but the early...
The limited accessibility of medical specialists for Alzheimer's disease (AD) can make obtaining an accurate diagnosis in a timely manner challenging and may influence prognosis. We investigated whether VUNO Med-DeepBrain AD (DBAD) using a deep learn...