AIMC Topic: Alzheimer Disease

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Differential Role for Hippocampal Subfields in Alzheimer's Disease Progression Revealed with Deep Learning.

Cerebral cortex (New York, N.Y. : 1991)
Mild cognitive impairment (MCI) is often considered the precursor of Alzheimer's disease. However, MCI is associated with substantially variable progression rates, which are not well understood. Attempts to identify the mechanisms that underlie MCI p...

Advances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future.

Journal of neuropathology and experimental neurology
Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the presence of neurofibrillary tangles and amyloid beta (Aβ) plaques in the brain. The disease was first described in 1906 by Alois Alzheimer, and since then, the...

A Machine Learning-Based Holistic Approach to Predict the Clinical Course of Patients within the Alzheimer's Disease Spectrum.

Journal of Alzheimer's disease : JAD
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative condition driven by multifactorial etiology. Mild cognitive impairment (MCI) is a transitional condition between healthy aging and dementia. No reliable biomarkers are available to predict t...

Utility of Machine Learning Approach with Neuropsychological Tests in Predicting Functional Impairment of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD
BACKGROUND: In assessing the levels of clinical impairment in dementia, a summary index of neuropsychological batteries has been widely used in describing the overall functional status.

Use of deep learning genomics to discriminate Alzheimer's disease and healthy controls.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly. Because gene is an important clinical risk factor resulting in AD, genomic studies, such as genome-wide association studies...

Nonlinear registration as an effective preprocessing technique for Deep learning based classification of disease.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
A number of machine learning (ML), and particularly in recent years, deep learning (DL) approaches have been proposed for automatic classification of Alzheimer's disease (AD) using brain structural magnetic resonance imaging (MRI) data. However, the ...

Input Agnostic Deep Learning for Alzheimer's Disease Classification Using Multimodal MRI Images.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Alzheimer's disease (AD) is a progressive brain disorder that causes memory and functional impairments. The advances in machine learning and publicly available medical datasets initiated multiple studies in AD diagnosis. In this work, we utilize a mu...

Data-Limited Deep Learning Methods for Mild Cognitive Impairment Classification in Alzheimer's Disease Patients.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Mild Cognitive Impairment (MCI) is the stage between the declining of normal brain function and the more serious decline of dementia. Alzheimer's disease (AD) is one of the leading forms of dementia. Although MCI does not always lead to AD, an early ...

Federated Learning via Conditional Mutual Learning for Alzheimer's Disease Classification on T1w MRI.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Data-driven deep learning has been considered a promising method for building powerful models for medical data, which often requires a large amount of diverse data to be sufficiently effective. However, the expensive cost of collecting and the privac...

Deep Learning on SDF for Classifying Brain Biomarkers.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Biomarkers are one of the primary medical signs to facilitate the early detection of Alzheimer's disease. The small beta-amyloid (Aβ) peptide is an important indicator for the disease. However, current methods to detect Aβ pathology are either invasi...