AIMC Topic: Animal Testing Alternatives

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Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility.

Toxicological sciences : an official journal of the Society of Toxicology Sep 1, 2018
Earlier we created a chemical hazard database via natural language processing of dossiers submitted to the European Chemical Agency with approximately 10 000 chemicals. We identified repeat OECD guideline tests to establish reproducibility of acute o...
Humans Machine Learning Reproducibility of Results Sensitivity and Specificity Animals Big Data Models, Theoretical Structure-Activity Relationship Data Mining Databases, Chemical Animal Testing Alternatives Hazardous Substances
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Evaluation of (indigenous drug) as oxidative stress down-regulator using serum-free explant culture system.

Indian journal of pharmacology Jan 1, 2018
CONTEXT: The importance of phytochemicals/natural products as potential therapeutic agents in the present context is gaining a lot of importance. India with a rich heritage of such preparations needs evaluation as potent drugs. Explant culture system...
Animals Male In Vitro Techniques Oxidative Stress India Mice Antioxidants Plant Extracts Dose-Response Relationship, Drug Liver Plants, Medicinal Animal Testing Alternatives Medicine, Ayurvedic
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[Challenges to Improve the Prediction Accuracy of the Non-clinical Tests for Human CNS Adverse Effects: Potentials of Artificial Intelligence and Human ESC/iPSC-derived Neurons].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Jan 1, 2018
Humans Artificial Intelligence Drug Discovery Cell Differentiation Drug Evaluation, Preclinical Neurons Central Nervous System Agents Neuroimaging Animal Testing Alternatives Induced Pluripotent Stem Cells Human Embryonic Stem Cells
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