AIMC Topic: beta-Galactosidase

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Enhancing the synthesis efficiency of galacto-oligosaccharides of a β-galactosidase from Paenibacillus barengoltzii by engineering the active and distal sites.

Food chemistry Apr 4, 2025
Previously, a glycoside hydrolase (GH) family 2 β-galactosidase (PbBGal2A) from Paenibacillus barengoltzii is characterized for its high transglycosylation capability. Here, the cryo-electron microscopy (cryo-EM) structure of PbBGal2A was determined,...
Bacterial Proteins Molecular Dynamics Simulation Oligosaccharides beta-Galactosidase Biocatalysis Catalytic Domain Galactose Protein Engineering Paenibacillus
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Anti-senescent drug screening by deep learning-based morphology senescence scoring.

Nature communications Jan 11, 2021
Advances in deep learning technology have enabled complex task solutions. The accuracy of image classification tasks has improved owing to the establishment of convolutional neural networks (CNN). Cellular senescence is a hallmark of ageing and is im...
Humans Neural Networks, Computer Deep Learning Hydrogen Peroxide Human Umbilical Vein Endothelial Cells Cellular Senescence Drug Evaluation, Preclinical beta-Galactosidase Cell Shape
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[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].

Zhonghua nan ke xue = National journal of andrology Mar 1, 2019
OBJECTIVE: To investigate the effect of the down-regulated expression of pituitary tumor-transforming gene 1 (PTTG1) on the senescence of human castration-resistant prostate cancer LNCaP-AI cells.
Humans Male Cell Line, Tumor Cell Proliferation RNA, Small Interfering Prostatic Neoplasms, Castration-Resistant Securin beta-Galactosidase
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[Role of high mobility group protein B1 in 
IL-1α-induced endothelial cell senescence].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Dec 28, 2017
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
 Methods: HUVECs were randomly divided into a control group, a IL-1α group...
Humans RNA, Messenger Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p16 HMGB1 Protein Human Umbilical Vein Endothelial Cells Sirtuin 1 Cellular Senescence Tumor Suppressor Protein p53 beta-Galactosidase Random Allocation Interleukin-1alpha
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