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Bioreactors

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Enhancing corn stalk-based anaerobic digestion with different types of zero-valent iron added during the acidification stage: Performance and mechanism.

Journal of environmental sciences (China)
Anaerobic digestion has been defined as a competitive approach to facilitate the recycling of corn stalks. However, few studies have focused on the role of direct interspecies electron transfer (DIET) pathway in the acidification stage under the addi...

Smart Sensor Control and Monitoring of an Automated Cell Expansion Process.

Sensors (Basel, Switzerland)
Immune therapy for cancer patients is a new and promising area that in the future may complement traditional chemotherapy. The cell expansion phase is a critical part of the process chain to produce a large number of high-quality, genetically modifie...

Development of a robotic cluster for automated and scalable cell therapy manufacturing.

Cytotherapy
BACKGROUND AIMS: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high ...

Optimizing neural network algorithms for submerged membrane bioreactor: A comparative study of OVAT and RSM hyperparameter optimization techniques.

Water science and technology : a journal of the International Association on Water Pollution Research
Hyperparameter tuning is an important process to maximize the performance of any neural network model. This present study proposed the factorial design of experiment for screening and response surface methodology to optimize the hyperparameter of two...

Statistical versus neural network-embedded swarm intelligence optimization of a metallo-neutral-protease production: activity kinetics and food industry applications.

Preparative biochemistry & biotechnology
An integrated approach involving response surface methodology (RSM) and artificial neural network-ant-colony hybrid optimization (ANN-ACO) was adopted to develop a bioprocess medium to increase the yield of neutral protease under submerged fermentat...

Application of a generalized hybrid machine learning model for the prediction of HS and VOCs removal in a compact trickle bed bioreactor (CTBB).

Chemosphere
This study presents a generalized hybrid model for predicting HS and VOCs removal efficiency using a machine learning model: K-NN (K - nearest neighbors) and RF (random forest). The approach adopted in this study enabled the (i) identification of odo...

Machine learning for high solid anaerobic digestion: Performance prediction and optimization.

Bioresource technology
Biogas production through anaerobic digestion (AD) is one of the complex non-linear biological processes, wherein understanding its dynamics plays a crucial role towards process control and optimization. In this work, a machine learning based biogas ...

Predicting thermodynamic adhesion energies of membrane fouling in planktonic anammox MBR via backpropagation neural network model.

Bioresource technology
Predicting thermodynamic adhesion energies was a critical strategy for mitigating membrane fouling. This study utilized a backpropagation (BP) neural network model to predict the thermodynamic adhesion energies associated with membrane fouling in a p...

A machine learning-based approach for improving plasmid DNA production in Escherichia coli fed-batch fermentations.

Biotechnology journal
Artificial Intelligence (AI) technology is spearheading a new industrial revolution, which provides ample opportunities for the transformational development of traditional fermentation processes. During plasmid fermentation, traditional subjective pr...

A data-driven approach for revealing the linkages between differences in electrochemical properties of biochar during anaerobic digestion using automated machine learning.

The Science of the total environment
Biochar is commonly used to enhance the anaerobic digestion of organic waste solids and wastewater, due to its electrochemical properties, which intensify the electron transfer of microorganisms attached to its large surface area. However, it is diff...