AIMC Topic: Carrier Proteins

Clear Filters Showing 21 to 30 of 31 articles

Linking of single-molecule experiments with molecular dynamics simulations by machine learning.

eLife May 3, 2018
Single-molecule experiments and molecular dynamics (MD) simulations are indispensable tools for investigating protein conformational dynamics. The former provide data, such as donor-acceptor distances, whereas the latter give atomistic information, ...
Protein Conformation Single Molecule Imaging Protein Folding Molecular Dynamics Simulation Fluorescence Resonance Energy Transfer Machine Learning Carrier Proteins
View on PubMed DOI

Structure-function properties of hypolipidemic peptides.

Journal of food biochemistry Mar 8, 2018
This review addresses the structure-function properties of hypolipidemic peptides. The cholesterol-lowering peptide (lactostatin: IIAEK) operates via a new regulatory pathway in the calcium-channel-related mitogen-activated protein kinase (MAPK) sign...
Atherosclerosis Oligopeptides Anti-Obesity Agents Amino Acid Sequence Seed Storage Proteins Humans Antigens, Plant Hypolipidemic Agents Carrier Proteins Structure-Activity Relationship Globulins Soybean Proteins Membrane Glycoproteins Apolipoprotein A-I Hyperlipidemias
View on PubMed DOI

Using Chou's general PseAAC to analyze the evolutionary relationship of receptor associated proteins (RAP) with various folding patterns of protein domains.

Journal of theoretical biology Feb 22, 2018
The receptor-associated protein (RAP) is an inhibitor of endocytic receptors that belong to the lipoprotein receptor gene family. In this study, a computational approach was tried to find the evolutionarily related fold of the RAP proteins. Through t...
Structure-Activity Relationship Models, Molecular Protein Conformation Support Vector Machine Carrier Proteins Evolution, Molecular Databases, Protein Computational Biology
View on PubMed DOI

Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.

Journal of pharmaceutical sciences Jun 1, 2016
The aim of this study was to develop an in silico prediction system to assess which of 7 categories of drug transporters (organic anion transporting polypeptide [OATP] 1B1/1B3, multidrug resistance-associated protein [MRP] 2/3/4, organic anion transp...
Support Vector Machine Carrier Proteins Lipids Biological Transport Molecular Weight Predictive Value of Tests Pharmaceutical Preparations Algorithms Computer Simulation Substrate Specificity Multidrug Resistance-Associated Proteins
View on PubMed DOI

Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors.

Frontiers in bioscience (Landmark edition) Feb 21, 2024
BACKGROUND: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: (), (), and (). CCM1 and...
Humans Protein Isoforms Receptors, Progesterone Proto-Oncogene Proteins Hemangioma, Cavernous, Central Nervous System Deep Learning Transcription Factors Carrier Proteins
View on PubMed DOI

circRNA-binding protein site prediction based on multi-view deep learning, subspace learning and multi-view classifier.

Briefings in bioinformatics Jan 17, 2022
Circular RNAs (circRNAs) generally bind to RNA-binding proteins (RBPs) to play an important role in the regulation of autoimmune diseases. Thus, it is crucial to study the binding sites of RBPs on circRNAs. Although many methods, including traditiona...
Carrier Proteins Binding Sites RNA, Circular Humans Deep Learning Computational Biology
View on PubMed DOI

Improved protein contact prediction using dimensional hybrid residual networks and singularity enhanced loss function.

Briefings in bioinformatics Nov 5, 2021
Deep residual learning has shown great success in protein contact prediction. In this study, a new deep residual learning-based protein contact prediction model was developed. Comparing with previous models, a new type of residual block hybridizing 1...
Software Reproducibility of Results Carrier Proteins Proteins Protein Interaction Mapping Deep Learning Protein Binding Computational Biology
View on PubMed DOI

Predicting MHC class I binder: existing approaches and a novel recurrent neural network solution.

Briefings in bioinformatics Nov 5, 2021
Major histocompatibility complex (MHC) possesses important research value in the treatment of complex human diseases. A plethora of computational tools has been developed to predict MHC class I binders. Here, we comprehensively reviewed 27 up-to-date...
Neural Networks, Computer Computational Biology Carrier Proteins Epitopes Binding Sites Web Browser Histocompatibility Antigens Class I Amino Acid Sequence Reproducibility of Results Deep Learning ROC Curve Protein Binding Machine Learning Software Databases, Factual
View on PubMed DOI

Identification of hormone binding proteins based on machine learning methods.

Mathematical biosciences and engineering : MBE Mar 22, 2019
The soluble carrier hormone binding protein (HBP) plays an important role in the growth of human and other animals. HBP can also selectively and non-covalently interact with hormone. Therefore, accurate identification of HBP is an important prerequis...
Hormones Analysis of Variance Carrier Proteins Databases, Protein Amino Acids Algorithms Computer Simulation Reproducibility of Results Computational Biology Support Vector Machine Animals Peptides Humans Machine Learning Software
View on PubMed DOI

Estimating glucose requirements of an activated immune system in growing pigs.

Journal of animal science Nov 1, 2017
Activated immune cells become obligate glucose utilizers, and a large i.v. lipopolysaccharide (LPS) dose causes insulin resistance and severe hypoglycemia. Therefore, study objectives were to quantify the amount of glucose needed to maintain euglycem...
Glucose Clamp Technique Body Temperature Immune System Blood Urea Nitrogen Animals Membrane Glycoproteins Insulin Resistance Swine Glucose Female Acute-Phase Proteins Fasting Lipopolysaccharides Hypoglycemia Blood Glucose Carrier Proteins
View on PubMed DOI
Popular Topics
Recent Journals