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Multidrug Resistance-Associated Proteins

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Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.

Journal of pharmaceutical sciences 27262201
The aim of this study was to develop an in silico prediction system to assess which of 7 categories of drug transporters (organic anion transporting polypeptide [OATP] 1B1/1B3, multidrug resistance-associated protein [MRP] 2/3/4, organic anion transp...
Algorithms Biological Transport Carrier Proteins Computer Simulation Lipids Molecular Weight Multidrug Resistance-Associated Proteins Pharmaceutical Preparations Predictive Value of Tests Substrate Specificity Support Vector Machine
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Machine learning-, rule- and pharmacophore-based classification on the inhibition of P-glycoprotein and NorA.

SAR and QSAR in environmental research 27667641
The efflux pumps P-glycoprotein (P-gp) in humans and NorA in Staphylococcus aureus are of great interest for medicinal chemists because of their important roles in multidrug resistance (MDR). The high polyspecificity as well as the unavailability of ...
Algorithms ATP Binding Cassette Transporter, Subfamily B, Member 1 Bacterial Proteins Databases, Chemical Drug Discovery Humans Ligands Machine Learning Multidrug Resistance-Associated Proteins Quantitative Structure-Activity Relationship Staphylococcus aureus
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Predicting Inhibitors for Multidrug Resistance Associated Protein-2 Transporter by Machine Learning Approach.

Combinatorial chemistry & high throughput screening 30360705
BACKGROUND: The efflux transporter multidrug resistance associated protein-2 belongs to ATP-binding cassette superfamily which plays an important role in multidrug resistance and drugdrug interactions. Efflux transporters are considered to be importa...
Algorithms Databases, Pharmaceutical Drug Discovery Machine Learning Molecular Structure Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins Quantitative Structure-Activity Relationship Support Vector Machine
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics 32930952
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Adolescent Adult Area Under Curve Asian People Cross-Over Studies Cytochrome P-450 CYP1A1 Deferasirox Drug Compounding Female Glucuronosyltransferase Half-Life Healthy Volunteers Humans Iron Chelating Agents Male Middle Aged Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins Neural Networks, Computer Polymorphism, Genetic Polymorphism, Single Nucleotide Predictive Value of Tests Young Adult
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