AIMC Topic: Multidrug Resistance-Associated Proteins

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Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.

Journal of pharmaceutical sciences Jun 1, 2016
The aim of this study was to develop an in silico prediction system to assess which of 7 categories of drug transporters (organic anion transporting polypeptide [OATP] 1B1/1B3, multidrug resistance-associated protein [MRP] 2/3/4, organic anion transp...
Substrate Specificity Lipids Multidrug Resistance-Associated Proteins Predictive Value of Tests Support Vector Machine Biological Transport Carrier Proteins Molecular Weight Pharmaceutical Preparations Algorithms Computer Simulation
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Integrating Bulk and Single-Cell Transcriptomics with Machine Learning Reveals a Heme Metabolism-Based Panel for Lung Adenocarcinoma Chemotherapy Resistance.

International journal of molecular sciences May 14, 2025
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with heme metabolism playing a critical role in tumor progression and treatment resistance. This study investigates the clinical implications of heme metabolism in LUAD, focus...
Antineoplastic Agents Gene Expression Profiling Cell Line, Tumor Single-Cell Analysis Prognosis Ferroptosis Transcriptome Adenocarcinoma of Lung Lung Neoplasms Female Cisplatin Humans Gene Expression Regulation, Neoplastic Multidrug Resistance-Associated Proteins Heme Machine Learning Multidrug Resistance-Associated Protein 2 Drug Resistance, Neoplasm
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Polymorphism, Genetic Deferasirox Half-Life Drug Compounding Multidrug Resistance-Associated Proteins Multidrug Resistance-Associated Protein 2 Cytochrome P-450 CYP1A1 Iron Chelating Agents Glucuronosyltransferase Predictive Value of Tests Area Under Curve Cross-Over Studies Healthy Volunteers Asian People Adolescent Polymorphism, Single Nucleotide Male Middle Aged Humans Neural Networks, Computer Young Adult Adult Female
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Predicting Inhibitors for Multidrug Resistance Associated Protein-2 Transporter by Machine Learning Approach.

Combinatorial chemistry & high throughput screening Jan 1, 2018
BACKGROUND: The efflux transporter multidrug resistance associated protein-2 belongs to ATP-binding cassette superfamily which plays an important role in multidrug resistance and drugdrug interactions. Efflux transporters are considered to be importa...
Machine Learning Algorithms Support Vector Machine Molecular Structure Drug Discovery Multidrug Resistance-Associated Proteins Quantitative Structure-Activity Relationship Multidrug Resistance-Associated Protein 2 Databases, Pharmaceutical
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Machine learning-, rule- and pharmacophore-based classification on the inhibition of P-glycoprotein and NorA.

SAR and QSAR in environmental research Sep 1, 2016
The efflux pumps P-glycoprotein (P-gp) in humans and NorA in Staphylococcus aureus are of great interest for medicinal chemists because of their important roles in multidrug resistance (MDR). The high polyspecificity as well as the unavailability of ...
Quantitative Structure-Activity Relationship Humans Multidrug Resistance-Associated Proteins Machine Learning Ligands Algorithms Staphylococcus aureus Databases, Chemical Drug Discovery Bacterial Proteins ATP Binding Cassette Transporter, Subfamily B, Member 1
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