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Computer-Aided Design

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Recent Trends in Computer-aided Drug Design for Anti-cancer Drug Discovery.

Current topics in medicinal chemistry
Cancer is considered one of the deadliest diseases globally, and continuous research is being carried out to find novel potential therapies for myriad cancer types that affect the human body. Researchers are hunting for innovative remedies to minimiz...

Accuracy and safety of a haptic operated and machine vision controlled collaborative robot for dental implant placement: A translational study.

Clinical oral implants research
OBJECTIVES: Multiple generations of medical robots have revolutionized surgery. Their application to dental implants is still in its infancy. Co-operating robots (cobots) have great potential to improve the accuracy of implant placement, overcoming t...

Accuracy and efficiency of robotic dental implant surgery with different human-robot interactions: An in vitro study.

Journal of dentistry
OBJECTIVES: This study aims to compare the surgical efficiency (preparation and operation time) and accuracy of implant placement between robots with different human-robot interactions.

Drug discovery: In silico dry data can bypass biological wet data?

British journal of pharmacology
The recent and extraordinary increase in computer power, along with the availability of efficient algorithms based on artificial intelligence, has prompted a large number of inexperienced scientists to challenge the complex and yet competitive world ...

Tooth morphology, internal fit, occlusion and proximal contacts of dental crowns designed by deep learning-based dental software: A comparative study.

Journal of dentistry
OBJECTIVES: This study compared the tooth morphology, internal fit, occlusion, and proximal contacts of dental crowns automatically generated via two deep learning (DL)-based dental software systems with those manually designed by an experienced dent...

De novo design of high-affinity binders of bioactive helical peptides.

Nature
Many peptide hormones form an α-helix on binding their receptors, and sensitive methods for their detection could contribute to better clinical management of disease. De novo protein design can now generate binders with high affinity and specificity ...

Deep learning-based automated detection of the dental crown finish line: An accuracy study.

The Journal of prosthetic dentistry
STATEMENT OF PROBLEM: The marginal fit of dental prostheses is a clinically significant issue, and dental computer-aided design software programs use automated methods to expedite the extraction of finish lines. The accuracy of these automated method...

CAD-CAM resin composites: Effective components for further development.

Dental materials : official publication of the Academy of Dental Materials
OBJECTIVE: This paper summarizes the effective components of computer-aided design and computer-aided manufacturing (CAD-CAM) resin composites that contribute to achieving greater mechanical properties and further development.

Effect of implant shape and length on the accuracy of robot-assisted immediate implant surgery: An in vitro study.

Clinical oral implants research
OBJECTIVES: To compare the accuracy of immediate implant placement of cylindrical implants (CI) and tapered implants (TI) of different lengths using a robotic dental implant system.