IEEE journal of biomedical and health informatics
Mar 18, 2019
Cell classification, especially that of white blood cells, plays a very important role in the field of diagnosis and control of major diseases. Compared to traditional optical microscopic imaging, hyperspectral imagery, combined with both spatial and...
SLAS discovery : advancing life sciences R & D
Jan 29, 2019
Multiparametric high-content imaging assays have become established to classify cell phenotypes from functional genomic and small-molecule library screening assays. Several groups have implemented machine learning classifiers to predict the mechanism...
IEEE journal of biomedical and health informatics
Dec 7, 2018
Even though convolutional neural networks (CNN) have been used for cell segmentation, they require pixel-level ground truth annotations. This paper proposes a multitask learning algorithm for cell detection and segmentation using CNNs. We use dot ann...
Automatic event detection in cell videos is essential for monitoring cell populations in biomedicine. Deep learning methods have advantages over traditional approaches for cell event detection due to their ability to capture more discriminative featu...
International journal of medical informatics
Nov 30, 2018
BACKGROUND: In recent years, cytological observations in the Rhinology field are being increasingly utilized. This development has taken place over the last two decades and has proven to be fundamental in defining new nosological entities and in driv...
Age-associated deterioration of cellular physiology leads to pathological conditions. The ability to detect premature aging could provide a window for preventive therapies against age-related diseases. However, the techniques for determining cellular...
IEEE journal of biomedical and health informatics
Oct 31, 2018
Recent advances in ultra-high-throughput microscopy have enabled a new generation of cell classification methodologies using image-based cell phenotypes alone. In contrast to current single-cell analysis techniques that rely solely on slow and costly...
IEEE journal of biomedical and health informatics
Feb 6, 2018
Fuzzy c-means (FCM) clustering algorithms have been proved to be effective image segmentation techniques. However, FCM clustering algorithms are sensitive to noises and initialization. They cannot effectively segment cell images with inhomogeneous gr...
Deep Convolutional Neural Networks (DCNN) have recently emerged as superior for many image segmentation tasks. The DCNN performance is however heavily dependent on the availability of large amounts of problem-specific training samples. Here we show t...
Efficient and robust cell detection serves as a critical prerequisite for many subsequent biomedical image analysis methods and computer-aided diagnosis (CAD). It remains a challenging task due to touching cells, inhomogeneous background noise, and l...
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