The Src Homology 2 (SH2) domain plays an important role in the signal transmission mechanism in organisms. It mediates the protein-protein interactions based on the combination between phosphotyrosine and motifs in SH2 domain. In this study, we desig...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
May 29, 2023
From out-competing grandmasters in chess to informing high-stakes healthcare decisions, emerging methods from artificial intelligence are increasingly capable of making complex and strategic decisions in diverse, high-dimensional and uncertain situat...
BACKGROUND: Segmentation of the Gross Tumor Volume (GTV) is a crucial step in the brachytherapy (BT) treatment planning workflow. Currently, radiation oncologists segment the GTV manually, which is time-consuming. The time pressure is particularly cr...
Immune receptor proteins play a key role in the immune system and have shown great promise as biotherapeutics. The structure of these proteins is critical for understanding their antigen binding properties. Here, we present ImmuneBuilder, a set of de...
Computational and mathematical methods in medicine
May 29, 2023
Medical imaging refers to the process of obtaining images of internal organs for therapeutic purposes such as discovering or studying diseases. The primary objective of medical image analysis is to improve the efficacy of clinical research and treatm...
At present, MRI scans are typically performed inside fully enclosed radiofrequency (RF) shielding rooms, posing stringent installation requirements and causing patient discomfort. We aim to eliminate electromagnetic interference (EMI) for MRI with no...
Clinical & experimental ophthalmology
May 28, 2023
Optical coherence tomography (OCT) is a non-invasive optical imaging modality, which provides rapid, high-resolution and cross-sectional morphology of macular area and optic nerve head for diagnosis and managing of different eye diseases. However, in...
Physical and engineering sciences in medicine
May 28, 2023
Parkinson's disease (PD) is characterized by slowed movements, speech disorders, an inability to control muscle movements, and tremors in the hands and feet. In the early stages of PD, the changes in these motor signs are very vague, so an objective ...
It is becoming increasingly attractive to detect human emotions using electroencephalography (EEG) brain signals. EEG is a reliable and cost-effective technology used to measure brain activities. This paper proposes an original framework for usabilit...
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