AIMC Topic: Dipeptidyl Peptidase 4

Clear Filters Showing 11 to 14 of 14 articles

Combination of machine learning and protein‑protein interaction network established one ATM‑DPP4‑TXN ferroptotic diagnostic model with experimental validation.

Molecular medicine reports Sep 1, 2025
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
Humans Machine Learning Biomarkers Gene Expression Profiling Sepsis Protein Interaction Maps Gene Regulatory Networks Computational Biology Databases, Genetic Ferroptosis Dipeptidyl Peptidase 4 Ataxia Telangiectasia Mutated Proteins Thioredoxins
View on PubMed DOI

Virtual Hydrolysis-Based Screening of Wheat-Derived DPP-IV Inhibitory Peptides: A Mechanistic Analysis Integrating Cell Experiments and Molecular Dynamics Simulations.

Journal of agricultural and food chemistry Aug 6, 2025
Dipeptidyl peptidase-IV (DPP-IV) inhibitors play a critical role in the treatment of diabetes and metabolic diseases. This study combines computational simulations with experimental validation to identify peptides with potential DPP-IV inhibitory act...
Humans Peptides Triticum Molecular Dynamics Simulation Amino Acid Sequence Hydrolysis Plant Proteins Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors
View on PubMed DOI

Bioactivity predictions and virtual screening using machine learning predictive model.

Journal of biomolecular structure & dynamics May 1, 2025
Recently, there has been significant attention on machine learning algorithms for predictive modeling. Prediction models for enzyme inhibitors are limited, and it is essential to account for chemical biases while developing them. The lack of repeatab...
Humans Machine Learning Algorithms Molecular Docking Simulation Drug Discovery Molecular Dynamics Simulation Drug Evaluation, Preclinical Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors
View on PubMed DOI

StructuralDPPIV: a novel deep learning model based on atom structure for predicting dipeptidyl peptidase-IV inhibitory peptides.

Bioinformatics (Oxford, England) Feb 1, 2024
MOTIVATION: Diabetes is a chronic metabolic disorder that has been a major cause of blindness, kidney failure, heart attacks, stroke, and lower limb amputation across the world. To alleviate the impact of diabetes, researchers have developed the next...
Humans Peptides Deep Learning Diabetes Mellitus Amino Acids Dipeptidyl Peptidase 4
View on PubMed DOI
Popular Topics
Recent Journals