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Dipeptidyl Peptidase 4

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Serum adipocytokines are associated with microalbuminuria in patients with type 1 diabetes and incipient chronic complications.

Diabetes & metabolic syndrome 30641752
AIMS: Recent studies have implicated possible contribution of adipocytokines in development and progression of microvascular complications in patients with type 1 diabetes (T1DM). The aim of our study was to investigate relationship between adipocyto...
Adipokines Adiponectin Adolescent Adult Aged Albuminuria Biomarkers Case-Control Studies Chronic Disease Diabetes Mellitus, Type 1 Diabetic Angiopathies Dipeptidyl Peptidase 4 Female Follow-Up Studies Humans Leptin Male Middle Aged Prognosis Resistin Young Adult
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Predicting DPP-IV inhibitors with machine learning approaches.

Journal of computer-aided molecular design 28155089
Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain...
Bayes Theorem Computer-Aided Design Diabetes Mellitus, Type 2 Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Drug Design Humans Machine Learning Molecular Docking Simulation Small Molecule Libraries
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Virtual screening of dipeptidyl peptidase-4 inhibitors using quantitative structure-activity relationship-based artificial intelligence and molecular docking of hit compounds.

Computational biology and chemistry 34800858
Dipeptidyl peptidase-4 (DPP-4) inhibitors are becoming an essential drug in the treatment of type 2 diabetes mellitus; however, some classes of these drugs exert side effects, including joint pain and pancreatitis. Studies suggest that these side eff...
Artificial Intelligence Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Drug Evaluation, Preclinical Humans Molecular Docking Simulation Quantitative Structure-Activity Relationship
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Integration of Deep Learning and Sequential Metabolism to Rapidly Screen Dipeptidyl Peptidase (DPP)-IV Inhibitors from .

Molecules (Basel, Switzerland) 37959800
Traditional Chinese medicine (TCM) possesses unique advantages in the management of blood glucose and lipids. However, there is still a significant gap in the exploration of its pharmacologically active components. Integrated strategies encompassing ...
Deep Learning Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Gardenia Iridoid Glycosides Molecular Docking Simulation
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Identification of active compounds as novel dipeptidyl peptidase-4 inhibitors through machine learning and structure-based molecular docking simulations.

Journal of biomolecular structure & dynamics 38100571
The enzyme dipeptidyl peptidase 4 (DPP4) is a potential therapeutic target for type 2 diabetes (T2DM). Many synthetic anti-DPP4 medications are available to treat T2DM. The need for secure and efficient medicines has been unmet due to the adverse sid...
Binding Sites Diabetes Mellitus, Type 2 Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Humans Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Neural Networks, Computer Protein Binding Sitagliptin Phosphate Structure-Activity Relationship
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Bioactivity predictions and virtual screening using machine learning predictive model.

Journal of biomolecular structure & dynamics 38217308
Recently, there has been significant attention on machine learning algorithms for predictive modeling. Prediction models for enzyme inhibitors are limited, and it is essential to account for chemical biases while developing them. The lack of repeatab...
Algorithms Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Drug Discovery Drug Evaluation, Preclinical Humans Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation
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StructuralDPPIV: a novel deep learning model based on atom structure for predicting dipeptidyl peptidase-IV inhibitory peptides.

Bioinformatics (Oxford, England) 38305458
MOTIVATION: Diabetes is a chronic metabolic disorder that has been a major cause of blindness, kidney failure, heart attacks, stroke, and lower limb amputation across the world. To alleviate the impact of diabetes, researchers have developed the next...
Amino Acids Deep Learning Diabetes Mellitus Dipeptidyl Peptidase 4 Humans Peptides
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Computational approaches for lead compound discovery in dipeptidyl peptidase-4 inhibition using machine learning and molecular dynamics techniques.

Computational biology and chemistry 39002224
The prediction of possible lead compounds from already-known drugs that may present DPP-4 inhibition activity imply a advantage in the drug development in terms of time and cost to find alternative medicines for the treatment of Type 2 Diabetes Melli...
Diabetes Mellitus, Type 2 Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Drug Discovery Humans Machine Learning Molecular Dynamics Simulation Molecular Structure
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