AIMC Topic: Ataxia Telangiectasia Mutated Proteins

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Combination of machine learning and protein‑protein interaction network established one ATM‑DPP4‑TXN ferroptotic diagnostic model with experimental validation.

Molecular medicine reports Jul 4, 2025
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
Gene Regulatory Networks Computational Biology Sepsis Protein Interaction Maps Dipeptidyl Peptidase 4 Ataxia Telangiectasia Mutated Proteins Thioredoxins Databases, Genetic Ferroptosis Humans Biomarkers Gene Expression Profiling Machine Learning
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Enhancing forensic investigations: Identifying bloodstains on various substrates through ATR-FTIR spectroscopy combined with machine learning algorithms.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Dec 10, 2023
The forensic analysis of bloodstains on various substrates plays a crucial role in criminal investigations. This study presents a novel approach for analyzing bloodstains using Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR...
Humans Machine Learning Algorithms Animals Discriminant Analysis Bayes Theorem Swine Ataxia Telangiectasia Mutated Proteins Least-Squares Analysis Spectroscopy, Fourier Transform Infrared
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Identification of sudden cardiac death from human blood using ATR-FTIR spectroscopy and machine learning.

International journal of legal medicine Dec 4, 2023
OBJECTIVE: The aim of this study is to identify a rapid, sensitive, and non-destructive auxiliary approach for postmortem diagnosis of SCD, addressing the challenges faced in forensic practice.
Ataxia Telangiectasia Mutated Proteins Death, Sudden, Cardiac Machine Learning Algorithms Biomarkers Spectroscopy, Fourier Transform Infrared Humans Artificial Intelligence
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Analysis and comparison of machine learning methods for species identification utilizing ATR-FTIR spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Dec 2, 2023
Accurate identification of insect species holds paramount significance in diverse fields as it facilitates a comprehensive understanding of their ecological habits, distribution range, and impact on both the environment and humans. While morphologica...
Ataxia Telangiectasia Mutated Proteins Spectrophotometry, Infrared Machine Learning Spectroscopy, Fourier Transform Infrared Humans
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Machine learning coarse-grained potentials of protein thermodynamics.

Nature communications Sep 15, 2023
A generalized understanding of protein dynamics is an unsolved scientific problem, the solution of which is critical to the interpretation of the structure-function relationships that govern essential biological processes. Here, we approach this prob...
Thermodynamics Physics Molecular Dynamics Simulation Ataxia Telangiectasia Mutated Proteins Machine Learning
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Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome.

Oxidative medicine and cellular longevity Dec 31, 2017
This study compared the antioxidant status and major lipophilic antioxidants in patients with ataxia-telangiectasia (AT) and Nijmegen breakage syndrome (NBS). Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), a...
Homeostasis Vitamin E Vitamin A Child Ubiquinone Male Oxidative Stress Nuclear Proteins Cell Cycle Proteins Adolescent Ataxia Telangiectasia Oxidation-Reduction Nijmegen Breakage Syndrome Humans Ataxia Telangiectasia Mutated Proteins Female
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Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis.

Experimental eye research Aug 1, 2025
OBJECTIVE: Cataract, a common age-related blinding eye disease, has a complex pathogenesis. This study aims to identify key genes and potential mechanisms associated with cataracts, offering new targets and insights for its prevention and treatment.
Humans Machine Learning Cell Proliferation Transcription Factors Apoptosis Animals Oxidative Stress Ataxia Telangiectasia Mutated Proteins Lens, Crystalline Epithelial Cells Gene Expression Regulation Cataract
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