The liquid and solid formulations of self-nano-emulsifying drug delivery systems (SNEDDS) have garnered significant attention in the pharmaceutical field for their ability to enhance the solubility and absorption of hydrophobic drugs. While both liqu...
International journal of pharmaceutics
Oct 27, 2025
Assessing the feasibility of a manufacturing route for a given formulation and process is a key initial step in drug product development. Additionally, the final product must meet a series of critical quality attributes to be considered suitable to m...
International journal of pharmaceutics
Oct 13, 2025
The disintegration behaviour of pharmaceutical tablets is a critical quality attribute influencing drug release, yet predicting it from formulation and processing parameters remains challenging due to complex underlying mechanisms. This work presents...
Ciprofloxacin (CFX) is a potent antibiotic for respiratory infections, but its poor solubility and high crystallinity limit its effectiveness in dry powder inhaler (DPI) delivery. Although soluble forms such as CFX hydrochloride are available, their ...
International journal of pharmaceutics
Oct 4, 2025
The transition from traditional batch to continuous pharmaceutical manufacturing puts additional demands on the efficient process development and operation. The comprehensive understanding of complex interdependencies between critical process paramet...
Poor oral bioavailability in most modern pharmaceuticals is primarily caused by poor aqueous solubility. Most NCEs (New Chemical Entities) and nearly 40% of drugs on the market fall into either Biopharmaceutical Classification System (BCS) class II o...
Biologics, including emerging engineered formats, can often exhibit poor developability profiles, complicating their translation into successful therapeutics. While formulation design can substantially mitigate some developability issues, it represen...
International journal of pharmaceutics
Sep 19, 2025
Ribbon splitting, a phenomenon that can occur during the roller compaction operation used in dry granulation processes, can lead to compromised granule uniformity, poor tabletability, and ultimately, off-specification tablet production. Despite its i...
International journal of pharmaceutics
Aug 24, 2025
PURPOSE: The development of a novel lipid-based formulation for apalutamide, a potent androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer (nmCRPC), is explored in this study.
International journal of pharmaceutics
Aug 16, 2025
This study aimed to explore the potential of a Machine learning (ML)-integrated Quality by design (QbD) process to formulate resveratrol (RES)-loaded polymeric nanoparticles (RES-PNPs) for potential use in transdermal drug delivery. The RES-PNPs were...
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