AIMC Topic: Electron Transport Complex I

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Prediction and analysis of redox-sensitive cysteines using machine learning and statistical methods.

Biological chemistry Jan 6, 2021
Reactive oxygen species are produced by a number of stimuli and can lead both to irreversible intracellular damage and signaling through reversible post-translational modification. It is unclear which factors contribute to the sensitivity of cysteine...
Humans Machine Learning Protein Processing, Post-Translational Oxidation-Reduction Cysteine Electron Transport Complex I
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Effects and inhibition mechanism of phenazine-1-carboxamide on the mycelial morphology and ultrastructure of Rhizoctonia solani.

Pesticide biochemistry and physiology Oct 24, 2017
The purpose of this research was to explore the effect of phenazine-1-carboxamide (PCN) on Rhizoctonia solani and to elucidate its mechanisms of action. The toxicity of PCN to R. solani was measured using a growth rate method. The results indicated t...
Real-Time Polymerase Chain Reaction Plant Roots Antifungal Agents Mitochondria Cell Wall Crops, Agricultural Plant Diseases Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mycelium Genes, Fungal Phenazines Chitin Synthase Electron Transport Complex I Rhizoctonia
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Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.

Scientific reports Jan 26, 2015
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberratio...
Humans Machine Learning Fibroblasts Reactive Oxygen Species Membrane Potential, Mitochondrial Mitochondria Electron Transport Complex I Chromans Citrate (si)-Synthase Leigh Disease Mitochondrial Diseases Oxidative Phosphorylation
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Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses.

Scientific reports May 14, 2025
Mitochondrial heterogeneity drives diverse cellular responses in neurodegenerative diseases, complicating the evaluation of mitochondrial dysfunction. In this study, we describe a high-throughput imaging and analysis approach to investigate cell-to-c...
Humans Single-Cell Analysis Mitochondria Neurons Electron Transport Complex I Induced Pluripotent Stem Cells Rotenone Oligomycins Antimycin A Electron Transport Complex III Mitochondrial Proton-Translocating ATPases
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