AIMC Topic: Mitochondrial Diseases
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Identification of immune-related mitochondrial metabolic disorder genes in septic shock using bioinformatics and machine learning.
Hereditas
Nov 28, 2024
PURPOSE: Mitochondria are involved in septic shock and inflammatory response syndrome, which severely affects the life security of patients. It is necessary to recognize and explore the immune-mitochondrial genes in septic shock.
The mining and construction of a knowledge base for gene-disease association in mitochondrial diseases.
Scientific reports
Dec 13, 2021
Mitochondrial diseases are a group of heterogeneous genetic metabolic diseases caused by mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) gene mutations. Mining the gene-disease association of mitochondrial diseases is helpful for understanding the pa...
Genes, the brain, and artificial intelligence in evolution.
Journal of human genetics
Jul 27, 2020
Three important systems, genes, the brain, and artificial intelligence (especially deep learning) have similar goals, namely, the maximization of likelihood or minimization of cross-entropy. Animal brains have evolved through predator-prey interactio...
Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.
Scientific reports
Jan 26, 2015
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberratio...
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