AIMC Topic: Integrases

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Improved serotonin neuron-specific viral vectors applicable for optogenetic manipulation and recording.

Journal of pharmacological sciences May 8, 2025
Serotonin neurons are central to the pathophysiology and therapeutics of mental disorders, including major depressive disorder, anxiety, and schizophrenia. Genetically modified mice make it possible to target serotonin neurons by selective expression...
Animals Mice Integrases Mice, Transgenic Genetic Vectors Optogenetics Serotonergic Neurons
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Virological Findings and Treatment Outcomes of Cases That Developed Dolutegravir Resistance in Malawi's National HIV Treatment Program.

Viruses Dec 23, 2023
Millions of Africans are on dolutegravir-based antiretroviral therapy (ART), but few detailed descriptions of dolutegravir resistance and its clinical management exist. We reviewed HIV drug resistance (HIVDR) testing application forms submitted betwe...
Humans HIV Infections Treatment Outcome Pyridones Oxazines Heterocyclic Compounds, 3-Ring Piperazines HIV Malawi Integrases
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Deep Learning Identifies Cardiomyocyte Nuclei With High Precision.

Circulation research Jun 3, 2020
Biomarkers Reproducibility of Results Animals Deep Learning Image Processing, Computer-Assisted Mice Fluorescent Dyes Troponin T Integrases Indoles Microscopy Myocytes, Cardiac Cell Nucleus Immunohistochemistry Mice, Transgenic Myosin Heavy Chains
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