AIMC Topic: Genetic Vectors

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Prediction of Adeno-Associated Virus Fitness with a Protein Language-Based Machine Learning Model.

Human gene therapy Apr 16, 2025
Adeno-associated virus (AAV)-based therapeutics have the potential to transform the lives of patients by delivering one-time treatments for a variety of diseases. However, a critical challenge to their widespread adoption and distribution is the high...
Dependovirus Genetic Vectors Capsid Proteins Capsid Humans Machine Learning Mutation Genetic Therapy
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Advances in AAV capsid engineering: Integrating rational design, directed evolution and machine learning.

Molecular therapy : the journal of the American Society of Gene Therapy Apr 1, 2025
Adeno-associated virus (AAV) has emerged as a highly promising vector for human gene therapy due to its favorable safety profile, versatility, and ability to transduce a wide range of tissues. However, natural AAV serotypes have shortcomings, includi...
Humans Machine Learning Animals Capsid Proteins Capsid Genetic Therapy Genetic Engineering Directed Molecular Evolution Dependovirus Genetic Vectors Transduction, Genetic
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Artificial Intelligence-Based Approaches for AAV Vector Engineering.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Feb 11, 2025
Adeno-associated virus (AAV) has emerged as a leading vector for gene therapy due to its broad host range, low pathogenicity, and ability to facilitate long-term gene expression. However, AAV vectors face limitations, including immunogenicity and ins...
Genetic Vectors Genetic Engineering Humans Dependovirus Artificial Intelligence Genetic Therapy
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Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning.

Nature communications May 28, 2021
The design of CRISPR gRNAs requires accurate on-target efficiency predictions, which demand high-quality gRNA activity data and efficient modeling. To advance, we here report on the generation of on-target gRNA activity data for 10,592 SpCas9 gRNAs. ...
Computational Biology CRISPR-Cas Systems HEK293 Cells Plasmids Humans Software Deep Learning Gene Editing RNA, Guide, CRISPR-Cas Systems Lentivirus Genetic Vectors
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Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning.

Frontiers in immunology Apr 27, 2021
A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, mu...
Dependovirus Humans Machine Learning Animals Genetic Therapy Genetic Vectors Capsid
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Deep diversification of an AAV capsid protein by machine learning.

Nature biotechnology Feb 11, 2021
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data wi...
HeLa Cells Genetic Vectors Capsid Proteins Dependovirus Humans Machine Learning
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Domain-Scan: Combinatorial Sero-Diagnosis of Infectious Diseases Using Machine Learning.

Frontiers in immunology Feb 10, 2021
The presence of pathogen-specific antibodies in an individual's blood-sample is used as an indication of previous exposure and infection to that specific pathogen (e.g., virus or bacterium). Measurement of the diagnostic antibodies is routinely achie...
Peptide Library Peptide Fragments Epitopes Amino Acid Sequence Oligonucleotides Hepatitis C HIV Antibodies High-Throughput Nucleotide Sequencing Humans Serologic Tests Polymerase Chain Reaction DNA, Recombinant AIDS Serodiagnosis Machine Learning DNA Barcoding, Taxonomic Hepatitis C Antibodies Antigen-Antibody Reactions HIV Envelope Protein gp160 Communicable Diseases HIV Core Protein p24 Base Sequence Hepatitis C Antigens HIV Infections Genetic Vectors
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SemanticGO: a tool for gene functional similarity analysis in Arabidopsis thaliana and rice.

Plant science : an international journal of experimental plant biology May 23, 2020
Gene or pathway functional similarities are important information for researchers. However, these similarities are often described sparsely and qualitatively. The latent semantic analysis of Arabidopsis thaliana (Arabidopsis) Gene Ontology (GO) data ...
Arabidopsis Oryza Semantics Genetic Vectors Genes, Plant Databases, Genetic Natural Language Processing Metabolic Networks and Pathways Gene Regulatory Networks
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Construction and characterization of recombinant adenovirus carrying a mouse TIGIT-GFP gene.

Genetics and molecular research : GMR Dec 29, 2015
Recombinant adenovirus vector systems have been used extensively in protein research and gene therapy. However, the construction and characterization of recombinant adenovirus is a tedious and time-consuming process. TIGIT is a recently discovered im...
Green Fluorescent Proteins Cell Line Adenoviridae Humans Gene Order Gene Expression Animals Genetic Vectors Recombinant Fusion Proteins Hepatocytes Mice Transduction, Genetic Receptors, Immunologic
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Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ.

The Journal of comparative neurology Jul 7, 2015
Generation of the primate cortex is characterized by the diversity of cortical precursors and the complexity of their lineage relationships. Recent studies have reported miscellaneous precursor types based on observer classification of cell biology f...
Cluster Analysis Unsupervised Machine Learning Stem Cells Markov Chains Macaca fascicularis Green Fluorescent Proteins Video Recording Hydrozoa Animals Brain Cell Lineage Pattern Recognition, Automated Stem Cell Niche Genetic Vectors Image Processing, Computer-Assisted Immunohistochemistry Microscopy, Confocal Tissue Culture Techniques
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