We proposed an ensemble convolutional neural network model to identify sgRNA high on-target activity in four crops and we used one-hot encoding and k-mers for sequence encoding. As an important component of the CRISPR/Cas9 system, single-guide RNA (s...
Journal of chemical information and modeling
Dec 28, 2020
Molecular scaffolds are widely used in drug design. Many methods and tools have been developed to utilize the information in scaffolds. Scaffold diversification is frequently used by medicinal chemists in tasks such as lead compound optimization, but...
BMC medical informatics and decision making
Dec 15, 2020
BACKGROUND: The Kentucky Cancer Registry (KCR) is a central cancer registry for the state of Kentucky that receives data about incident cancer cases from all healthcare facilities in the state within 6 months of diagnosis. Similar to all other U.S. a...
Computational intelligence and neuroscience
Dec 12, 2020
In the era of the rapid development of today's Internet, people often feel overwhelmed by vast official news streams or unofficial self-media tweets. To help people obtain the news topics they care about, there is a growing need for systems that can ...
Drawing a distinction between mobile and non-mobile Internet Use Disorders is an important step to clarify blurred current concepts in the field of behavioral addictions. Similarly, future technological advances related to virtual or augmented realit...
Persons who inject drugs (PWID) are at increased risk for overdose death (ODD), infections with HIV, hepatitis B (HBV) and hepatitis C virus (HCV), and noninfectious health conditions. Spatiotemporal identification of PWID communities is essential fo...
Recently, more personalized travel methods have emerged in the tourism industry, such as individual travel and self-guided travel. The service models of traditional tourism limit the diversity of service options and cannot fully meet the individual n...
The advancements of information technology and related processing techniques have created a fertile base for progress in many scientific fields and industries. In the fields of drug discovery and development, machine learning techniques have been use...
Comprehensive analysis that aims to understand the topology of real-world networks and the development of algorithms that replicate their characteristics has been significant research issues. Although the accuracy of newly developed network protocols...
BACKGROUND: As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functions such as RNA metabolism and cell fate decision. Through accurate identification of 5-meth...
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