AIMC Topic: Muscarinic Antagonists

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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

Respiratory research May 8, 2025
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
Double-Blind Method Drug Therapy, Combination Drug Substitution Treatment Outcome Drug Combinations Administration, Inhalation Bronchodilator Agents Adrenergic beta-2 Receptor Agonists Muscarinic Antagonists Adrenal Cortex Hormones Female Aged Male Middle Aged Pulmonary Disease, Chronic Obstructive Humans
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Assessing the anticholinergic cognitive burden classification of putative anticholinergic drugs using drug properties.

British journal of clinical pharmacology Jun 11, 2024
AIMS: This study evaluated the use of machine learning to leverage drug absorption, distribution, metabolism and excretion (ADME) data together with physicochemical and pharmacological data to develop a novel anticholinergic burden scale and compare ...
Computer Simulation Blood-Brain Barrier Cognition Humans Machine Learning Biological Availability Muscarinic Antagonists Cholinergic Antagonists Models, Biological ATP Binding Cassette Transporter, Subfamily B, Member 1
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Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval.

Expert opinion on investigational drugs Jul 6, 2023
INTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological processes underlying the disease deterioration are still needed. Artificial Intelligence (AI) via Mach...
Bayes Theorem Muscarinic Antagonists Bronchodilator Agents Adrenergic beta-2 Receptor Agonists Administration, Inhalation Humans Machine Learning Artificial Intelligence Pulmonary Disease, Chronic Obstructive
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Physiological based pharmacokinetic modeling to estimate in vivo Ki of ketoconazole on renal P-gp using human drug-drug interaction study result of fesoterodine and ketoconazole.

Drug metabolism and pharmacokinetics Nov 15, 2017
This study was conducted to estimate in vivo inhibition constant (Ki) of ketoconazole on renal P-glycoprotein (P-gp) using human drug-drug interaction (DDI) study result of fesoterodine and ketoconazole. Fesoterodine is a prodrug which is extensively...
Drug Interactions Cross-Over Studies Ketoconazole Muscarinic Antagonists Humans Benzhydryl Compounds Male Models, Biological Cytochrome P-450 CYP3A Inhibitors Kidney ATP Binding Cassette Transporter, Subfamily B, Member 1 Liver
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Histopathologic and Urodynamic Effects of the Anticholinergic Drugs Oxybutynin, Tolterodine, and Trospium on the Bladder.

Lower urinary tract symptoms Mar 6, 2015
OBJECTIVES: This study aimed to evaluate the effects of intravesical instillation of the anticholinergic drugs oxybutynin, tolterodine, and trospium on bladder capacity and histopathological changes in the bladder mucosa.
Urothelium Tolterodine Tartrate Urological Agents Muscarinic Antagonists Urinary Bladder Mandelic Acids Nortropanes Benzilates Male Rabbits Animals Random Allocation
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Spasmolytic activity of Aquilariae Lignum Resinatum extract on gastrointestinal motility involves muscarinic receptors, calcium channels and NO release.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Aquilariae Lignum Resinatum (ALR), the dry rhizome of Aquilaria agallocha R. (Thymelaeaeeae), has been widely used to treat emesis, stomachache and gastrointestinal dysfunction.
Calcium Channels Rats Gastric Emptying Parasympatholytics Random Allocation Nitric Oxide Gastrointestinal Motility Calcium Channel Blockers Muscarinic Antagonists Thymelaeaceae Dose-Response Relationship, Drug Plant Extracts Organ Culture Techniques Receptors, Muscarinic Animals Rats, Wistar Mice
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