AIMC Topic: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

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Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.

Nature neuroscience Jul 25, 2019
Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins spread through the brain along anatomically connected networks, prompting progressive decline. Recently, mouse models have recapitulated the cell-to-cell tran...
Neural Networks, Computer Brain Female Animals Male Mice Models, Neurological Mice, Inbred C57BL Brain Mapping alpha-Synuclein Neurons Cell Death Linear Models Connectome Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Network abnormalities among non-manifesting Parkinson disease related LRRK2 mutation carriers.

Human brain mapping Feb 21, 2019
Non-manifesting carriers (NMC) of the G2019S mutation in the LRRK2 gene represent an "at risk" group for future development of Parkinson's disease (PD) and have demonstrated task related fMRI changes. However, resting-state networks have received les...
Humans Machine Learning Female Adult Male Middle Aged Magnetic Resonance Imaging Parkinson Disease Connectome Nerve Net Heterozygote Cerebrum Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Journal of chemical information and modeling Jun 9, 2025
The leucine-rich repeat kinase 2 (LRRK2) is the most mutated gene in familial Parkinson's disease, and its mutations lead to pathogenic hallmarks of the disease. The LRRK2 WDR domain is an understudied drug target for Parkinson's disease, with no kno...
Humans Machine Learning Protein Binding Protein Domains Molecular Dynamics Simulation Ligands Protein Kinase Inhibitors Thermodynamics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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