AIMC Topic: Machine Learning

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Integration of A Deep Learning Classifier with A Random Forest Approach for Predicting Malonylation Sites.

Genomics, proteomics & bioinformatics
As a newly-identified protein post-translational modification, malonylation is involved in a variety of biological functions. Recognizing malonylation sites in substrates represents an initial but crucial step in elucidating the molecular mechanisms ...

Evolving Gaussian Process Autoregression Based Learning of Human Motion Intent Using Improved Energy Kernel Method of EMG.

IEEE transactions on bio-medical engineering
Continuous human motion intent learning may be modeled using a Gaussian process (GP) autoregression based evolving system to cope with the unspecified and time-varying motion patterns. Electromyography (EMG) signals are the primary input. GP is used ...

DeepNEU: cellular reprogramming comes of age - a machine learning platform with application to rare diseases research.

Orphanet journal of rare diseases
BACKGROUND: Conversion of human somatic cells into induced pluripotent stem cells (iPSCs) is often an inefficient, time consuming and expensive process. Also, the tendency of iPSCs to revert to their original somatic cell type over time continues to ...

A classification framework for exploiting sparse multi-variate temporal features with application to adverse drug event detection in medical records.

BMC medical informatics and decision making
BACKGROUND: Adverse drug events (ADEs) as well as other preventable adverse events in the hospital setting incur a yearly monetary cost of approximately $3.5 billion, in the United States alone. Therefore, it is of paramount importance to reduce the ...

EEG correlation at a distance: A re-analysis of two studies using a machine learning approach.

F1000Research
In this paper, data from two studies relative to the relationship between the electroencephalogram (EEG) activities of two isolated and physically separated subjects were re-analyzed using machine-learning algorithms. The first dataset comprises the...

Computational prediction of diagnosis and feature selection on mesothelioma patient health records.

PloS one
BACKGROUND: Mesothelioma is a lung cancer that kills thousands of people worldwide annually, especially those with exposure to asbestos. Diagnosis of mesothelioma in patients often requires time-consuming imaging techniques and biopsies. Machine lear...

A review on machine learning methods for in silico toxicity prediction.

Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
In silico toxicity prediction plays an important role in the regulatory decision making and selection of leads in drug design as in vitro/vivo methods are often limited by ethics, time, budget, and other resources. Many computational methods have bee...

Machine learning models for predicting endocrine disruption potential of environmental chemicals.

Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
We introduce here ML4Tox, a framework offering Deep Learning and Support Vector Machine models to predict agonist, antagonist, and binding activities of chemical compounds, in this case for the estrogen receptor ligand-binding domain. The ML4Tox mode...

Computational Prediction of Human Disease- Associated circRNAs Based on Manifold Regularization Learning Framework.

IEEE journal of biomedical and health informatics
The accumulating evidences regarding circular RNAs (circRNAs) indicate that they play crucial roles in a wide range of biological processes and participate in tumorigenesis and progression. The number of newly discovered circRNAs have increased drama...