PURPOSE: This study aims to develop a deep-learning-based software capable of detecting and differentiating microaneurysms (MAs) as hyporeflective or hyperreflective on structural optical coherence tomography (OCT) images in patients with non-prolife...
Translational vision science & technology
Aug 1, 2022
PURPOSE: Accurate segmentation of microaneurysms (MAs) from adaptive optics scanning laser ophthalmoscopy (AOSLO) images is crucial for identifying MA morphologies and assessing the hemodynamics inside the MAs. Herein, we introduce AOSLO-net to perfo...
In diabetic retinopathy (DR), the early signs that may lead the eyesight towards complete vision loss are considered as microaneurysms (MAs). The shape of these MAs is almost circular, and they have a darkish color and are tiny in size, which means t...
Proceedings of the National Academy of Sciences of the United States of America
Mar 30, 2021
Understanding the mechanics of blood flow is necessary for developing insights into mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of technologies available for assessing in vivo flow fields, in vitro method...
Translational vision science & technology
Dec 1, 2020
PURPOSE: Heatmapping techniques can support explainability of deep learning (DL) predictions in medical image analysis. However, individual techniques have been mainly applied in a descriptive way without an objective and systematic evaluation. We in...
: To describe the development and validation of an artificial intelligence-based, deep learning algorithm (DeepDR) for the detection of diabetic retinopathy (DR) in retinal fundus photographs. : Five hundred fundus images, which had detailed labellin...
BACKGROUND: As one of the major complications of diabetes, diabetic retinopathy (DR) is a leading cause of visual impairment and blindness due to delayed diagnosis and intervention. Microaneurysms appear as the earliest symptom of DR. Accurate and re...
Advances in experimental medicine and biology
Jan 1, 2020
At medical checkups or mass screenings, the fundus examination is effective for early detection of systemic hypertension, arteriosclerosis, diabetic retinopathy, etc. In most cases, ophthalmologists and physicians grade retinal images by the conditio...
BACKGROUND AND OBJECTIVES: Diabetic retinopathy (DR) is the leading cause of blindness worldwide, and therefore its early detection is important in order to reduce disease-related eye injuries. DR is diagnosed by inspecting fundus images. Since micro...
BACKGROUND: Convolution neural networks have been considered for automatic analysis of fundus images to detect signs of diabetic retinopathy but suffer from low sensitivity.