AIMC Topic: MicroRNAs

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Multi-omics integration method based on attention deep learning network for biomedical data classification.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Integrating multi-omics data for the comprehensive analysis of the biological processes in human diseases has become one of the most challenging tasks of bioinformatics. Deep learning (DL) algorithms have recently become one...

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning.

International journal of molecular sciences
Aberrant miRNA expression has been associated with a large number of human diseases. Therefore, targeting miRNAs to regulate their expression levels has become an important therapy against diseases that stem from the dysfunction of pathways regulated...

miRBind: A Deep Learning Method for miRNA Binding Classification.

Genes
The binding of microRNAs (miRNAs) to their target sites is a complex process, mediated by the Argonaute (Ago) family of proteins. The prediction of miRNA:target site binding is an important first step for any miRNA target prediction algorithm. To dat...

Nonlinear decision-making with enzymatic neural networks.

Nature
Artificial neural networks have revolutionized electronic computing. Similarly, molecular networks with neuromorphic architectures may enable molecular decision-making on a level comparable to gene regulatory networks. Non-enzymatic networks could in...

Deep Learning-Based Medical Data Association Rules to Explore the Connectivity and Regulation Mechanism of miRNA-mRNA Network in Myocarditis.

Computational and mathematical methods in medicine
Acute, chronic myocarditis as myocardial localized or diffuse inflammation lesions is usually involving cardiac function in patients with severe adverse outcomes such as heart failure, sudden death, and no unified, but its pathogenesis clinical is ma...

A miRNA Target Prediction Model Based on Distributed Representation Learning and Deep Learning.

Computational and mathematical methods in medicine
MicroRNAs (miRNAs) are a kind of noncoding RNA, which plays an essential role in gene regulation by binding to messenger RNAs (mRNAs). Accurate and rapid identification of miRNA target genes is helpful to reveal the mechanism of transcriptome regulat...

A deep learning method for miRNA/isomiR target detection.

Scientific reports
Accurate identification of microRNA (miRNA) targets at base-pair resolution has been an open problem for over a decade. The recent discovery of miRNA isoforms (isomiRs) adds more complexity to this problem. Despite the existence of many methods, none...

MD-MLI: Prediction of miRNA-lncRNA Interaction by Using Multiple Features and Hierarchical Deep Learning.

IEEE/ACM transactions on computational biology and bioinformatics
Long non-coding RNA(lncRNA) can interact with microRNA(miRNA) and play an important role in inhibiting or activating the expression of target genes and the occurrence and development of tumors. Accumulating studies focus on the prediction of miRNA-ln...

Exploring the Study of miR-1301 Inhibiting the Proliferation and Migration of Squamous Cell Carcinoma YD-38 Cells through PI3K/AKT Pathway under Deep Learning Medical Images.

Computational intelligence and neuroscience
With the rapid development and application of deep learning medical image recognition, natural language processing, and other fields, at the same time, deep learning has become the most popular research direction in the field of image processing and ...

AIME: Autoencoder-based integrative multi-omics data embedding that allows for confounder adjustments.

PLoS computational biology
In the integrative analyses of omics data, it is often of interest to extract data representation from one data type that best reflect its relations with another data type. This task is traditionally fulfilled by linear methods such as canonical corr...