AIMC Topic: Misonidazole

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Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET.

Molecular oncology Dec 22, 2015
BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular...
Humans Female Breast Neoplasms Animals Cell Line, Tumor Mice Angiogenesis Inhibitors Mice, Nude Pancreatic Neoplasms Breast Positron-Emission Tomography Quinolones Neovascularization, Pathologic Pancreas Cell Hypoxia Fluorine Radioisotopes Benzimidazoles Antimetabolites, Antineoplastic Deoxycytidine Gemcitabine Misonidazole
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