As a result of rapidly accelerating artificial intelligence (AI) capabilities, multiple national governments and multinational bodies have launched efforts to address safety, security and ethics issues related to AI models. One high priority among th...
Occupancy models estimate a species' occupancy probability while accounting for imperfect detection, but often overlook the issue of false-positive detections. This problem of false positives has gained attention recently with the rapid advancement o...
Despite the increasing use of inertial measurement units (IMUs) and machine learning techniques for gait analysis, there remains a gap in which feature selection methods are best tailored for gait time series prediction. This study explores the impac...
A successful drug needs to combine several properties including high potency and good pharmacokinetic (PK) properties to sustain efficacious plasma concentration over time. To estimate required doses for preclinical animal efficacy models or for the ...
For years, a main focus of ecological research has been to better understand the complex dynamical interactions between species that comprise food webs. Using the connectance properties of a widely explored synthetic food web called the cascade model...
PURPOSE: Voriconazole (VCZ) is a first-line treatment for invasive fungal disease, characterized by a narrow therapeutic window and significant inter-individual variability. It is primarily metabolized by the liver, the function of which declines wit...
Pharmacokinetic data are not generally available for evaluating the toxicological potential of food chemicals. A simplified physiologically based pharmacokinetic (PBPK) model has been established to evaluate internal exposures to chemicals in rats or...
Tumour necrosis factors (TNFs) are key players in processes such as inflammation, cancer development, and autoimmune diseases. However, accurately identifying TNFs remains challenging because of their complex interactions with other cytokines. Althou...
Antibiotic pollution in the environment can significantly impact soil microorganisms, such as altering the soil microbial community or emerging antibiotic-resistant bacteria. We propose three machine learning (ML) methods to investigate antibiotics' ...
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to create an AI virtual cell (AIVC), a mult...
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