Clinical pharmacology and therapeutics
May 6, 2024
Levothyroxine is one of the most prescribed drugs in the western world. Dosing is challenging due to high-interindividual differences in effective dosage and the narrow therapeutic window. Model-informed precision dosing (MIPD) using machine learning...
CONTEXT: Computational modeling involves the use of computer simulations and models to study and understand real-world phenomena. Its application is particularly relevant in the study of potential interactions between biological elements. It is a pro...
Clinical trials involving systemic neoadjuvant treatments in breast cancer aim to shrink tumors before surgery while simultaneously allowing for controlled evaluation of biomarkers, toxicity, and suppression of distant (occult) metastatic disease. Ye...
Medical & biological engineering & computing
May 2, 2024
Accurate determination of body segment parameters is crucial for studying human movement and joint forces using musculoskeletal (MSK) models. However, existing methods for predicting segment mass have limited generalizability and sensitivity to body ...
This paper is concerned with a kind of Bobwhite quail population model where the parameters and initial values are positive parabolic fuzzy numbers. According to g-division of fuzzy sets and based on the symmetrical parabolic fuzzy numbers, the cond...
BACKGROUND: Pathogenic parasites are responsible for multiple diseases, such as malaria and Chagas disease, in humans and livestock. Traditionally, pathogenic parasites have been largely an evasive topic for vaccine design, with most successful vacci...
Time-series data are common in biomechanical studies. These data often undergo pre-processing steps such as time normalization or filtering prior to use in further analyses, including deep-learning classification. In this context, it remains unclear ...
BACKGROUND: Gastric cancer (GC) is a common and aggressive type of cancer worldwide. Despite recent advancements in its treatment, the prognosis for patients with GC remains poor. Understanding the mechanisms of cell death in GC, particularly those r...
Journal of chemical information and modeling
Apr 19, 2024
Artificial intelligence is expected to help identify excellent candidates in drug discovery. However, we face a lack of data, as it is time-consuming and expensive to acquire raw data perfectly for many compounds. Hence, we tried to develop a novel q...
It is unclear how animals with radial symmetry control locomotion without a brain. Using a combination of experiments, mathematical modeling, and robotics, we tested the extent to which this control emerges in sea stars (Protoreaster nodosus) from th...
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