AIMC Topic: Mutagenicity Tests

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Development of Machine Learning-Based Models for Mutagenicity Predictions with Applications to Non-Sugar Sweeteners.

Molecular informatics Jun 1, 2025
Artificial sweeteners, often known as non-sugar sweeteners (NSSs), have been utilized as food additives since World War II. However, there is also concern regarding the mutagenicity potential of NSSs. Every new chemical registration in the food and p...
Machine Learning Mutagens Mutagenicity Tests Sweetening Agents
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Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms.

The Journal of toxicological sciences Jan 1, 2020
2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most widely used herbicides in the world, but its mutagenic and carcinogenic potential is still controversial. We simulated environmental exposure to 2,4-D, with the objective of evaluating the gen...
Machine Learning Algorithms Animals Male Time Factors Mice Rats, Wistar DNA Damage Environmental Exposure Herbicides Comet Assay Mutagens Inhalation Exposure Micronucleus Tests Mutagenicity Tests 2,4-Dichlorophenoxyacetic Acid Carcinogens
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Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals.

Toxicological sciences : an official journal of the Society of Toxicology Mar 1, 2018
The in vitro MultiFlow DNA Damage assay multiplexes p53, γH2AX, phospho-histone H3, and polyploidization biomarkers into 1 flow cytometric analysis (Bryce, S. M., Bernacki, D. T., Bemis, J. C., and Dertinger, S. D. (2016). Genotoxic mode of action pr...
Humans Machine Learning Biomarkers Cell Line, Tumor DNA Damage Flow Cytometry Mutagens Mutagenicity Tests Histones
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Antigenotoxic and apoptotic activities of essential oil of Correa.

Indian journal of pharmacology Jan 1, 2016
OBJECTIVE: To study antigenotoxic and apoptotic activities of hydrodistilled essential oil from the leaves of Correa.
Humans Animals Hydrogen Peroxide Oils, Volatile Mice Plant Extracts Cell Proliferation Apoptosis Dose-Response Relationship, Drug Rutaceae DNA Damage HeLa Cells 3T3-L1 Cells Mutagenicity Tests
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