AIMC Topic: Pichia
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Modeling and Optimization of an Enhanced Soft Sensor for the Fermentation Process of .
Sensors (Basel, Switzerland)
May 9, 2024
This paper proposes a novel soft sensor modeling approach, MIC-TCA-INGO-LSSVM, to address the decline in performance of soft sensor models during the fermentation process of , caused by changes in working conditions. Initially, the transfer component...
CPV of the Future: AI-Powered Continued Process Verification for Bioreactor Processes.
PDA journal of pharmaceutical science and technology
Sep 19, 2022
According to the standard guidelines by the FDA, process validation in biopharma manufacturing encompasses a life cycle consisting of three stages: process design (PD), process qualification (PQ), and continued process verification (CPV). The validit...
Accurate and cost-effective prediction of HBsAg titer in industrial scale fermentation process of recombinant Pichia pastoris by using neural network based soft sensor.
Biotechnology and applied biochemistry
Jun 24, 2019
In the current work, the attempt was made to apply best-fitted artificial neural network (ANN) architecture and the respective training process for predicting final titer of hepatitis B surface antigen (HBsAg), produced intracellularly by recombinant...
Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg.
Preparative biochemistry & biotechnology
Feb 1, 2019
Artificial neural networking (ANN) seems to be a promising soft sensor for implementing current approaches of quality by design (QbD) and process analytical technologies (PAT) in the biopharmaceutical industry. In this study, we aimed to implement be...
Functional expression of porcine interferon-α using a combinational strategy in Pichia pastoris GS115.
Enzyme and microbial technology
Dec 10, 2018
Porcine interferon-α (pIFN-α) could be used as the vaccine adjuvant to enhance the antiviral ability of porcine in swine industry. In here, a combinational strategy integrating codon optimization, multiple gene insertion, strong AOX1 promoter, and ef...
A novel aspartic protease from Rhizomucor miehei expressed in Pichia pastoris and its application on meat tenderization and preparation of turtle peptides.
Food chemistry
Oct 23, 2017
A novel aspartic protease gene (RmproA) was cloned from the thermophilic fungus Rhizomucor miehei CAU432 and expressed in Pichia pastoris. The RmproA was successfully expressed in P. pastoris as an active extracellular protease. High protease activit...
Expression of rabies virus glycoprotein in the methylotrophic yeast Pichia pastoris.
Biotechnology and applied biochemistry
Apr 14, 2016
Rabies is a fatal disease that can be prevented by vaccination. Different approaches were investigated to develop novel human rabies vaccines with improved features compared to the current available vaccines, among them is the use of heterologous gen...
[Construction and high-density fermentation of alkaline pectate lyase high-yield yeast].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Dec 25, 2017
Pectate lyase is widely applied in ramie degumming and fabric bioscouring in the textile industry. Compared to conventional processes that involve high alkaline and high temperature treatment, enzyme based treatments have significant advantages in fi...
[Gene optimization and efficient expression of Trichoderma reesei Cel5A in Pichia pastoris].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Oct 25, 2016
Deficient activity of endo-1,4-beta-glucanase II (Cel5A) secreted by Trichoderma reesei is one of the challenges involved in effective cellulase saccharification of cellulosic substrates. Therefore, we expressed Cel5A in Pichia pastoris by constructi...
[Enhancement of Coprinus cinereus peroxidase in Pichia pastoris by co-expression chaperone PDI and Ero1].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Dec 1, 2015
The 1,095 bp gene encoding peroxidase from Coprinus cinereus was synthesized and integrated into the genome of Pichia pastoris with a highly inducible alcohol oxidase. The recombinant CiP (rCiP) fused with the a-mating factor per-pro leader sequence ...
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