AIMC Topic: Hepatitis B virus
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Integrating bulk and single cell sequencing data to identify prognostic biomarkers and drug candidates in HBV associated hepatocellular carcinoma.
Scientific reports
Jul 18, 2025
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC), yet the mechanisms by which HBV triggers HCC and how it interacts with the immune system remain largely undefined. In this study, 53 immune-related key genes invol...
Deep learning-driven insights into the transmission dynamics of hepatitis B virus with treatment.
Scientific reports
Jul 3, 2025
Viral infections have spread globally, profoundly affecting social and economic aspects of life and causing widespread suffering. Infection caused by the hepatitis B virus (HBV) is one of the significant global health challenges but can be effectivel...
Construction and validation of HBV-ACLF bacterial infection diagnosis model based on machine learning.
BMC infectious diseases
Jul 1, 2025
OBJECTIVE: To develop and validate a novel diagnostic model for detecting bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) using advanced machine learning algorithms. The focus is on improving ...
Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.
Scientific reports
May 9, 2025
Medical interns are at high risk of acquiring Hepatitis B Virus (HBV) infection during their training. HBV vaccination is the most effective measure to reduce the global incidence of HBV. The duration of protection after HBV vaccination is still cont...
A prediction model based on machine learning: prognosis of HBV-induced HCC male patients with smoking and drinking habits after local ablation treatment.
Frontiers in immunology
Mar 28, 2025
BACKGROUND: Liver cancer, particularly hepatocellular carcinoma (HCC), is a major health concern globally and in China, possibly shows recurrence after ablation treatment in high-risk patients. This study investigates the prognosis of early-stage mal...
Identification of Biomarkers for Response to Interferon in Chronic Hepatitis B Based on Bioinformatics Analysis and Machine Learning.
Viral immunology
Feb 24, 2025
Interferon (IFN) is a pivotal agent against hepatitis B virus (HBV) in clinic, but there is a lack of accurate biomarkers to predict the response to IFN therapy in patients with chronic hepatitis B (CHB). Our study aimed to investigate potential targ...
Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning.
Frontiers in immunology
Jan 27, 2025
BACKGROUND: Immune checkpoint inhibitors have proven efficacy against hepatitis B-virus positive hepatocellular. However, Immunotherapy-related adverse reactions are still a major challenge faced by tumor immunotherapy, so it is urgent to establish n...
A multi-layer neural network approach for the stability analysis of the Hepatitis B model.
Computational biology and chemistry
Nov 8, 2024
In the present study, we explore the dynamics of Hepatitis B virus infection, a significant global health issue, through a newly developed dynamics system. This model is distinguished by its inclusion of asymptomatic carriers and the impact of vaccin...
Machine learning models to further identify advantaged populations that can achieve functional cure of chronic hepatitis B virus infection after receiving Peg-IFN alpha treatment.
International journal of medical informatics
Oct 22, 2024
OBJECTIVE: Functional cure is currently the highest goal of hepatitis B virus(HBV) treatment.Pegylated interferon(Peg-IFN) alpha is an important drug for this purpose,but even in the hepatitis B e antigen(HBeAg)-negative population,there is still a p...
Predictive modeling of hepatitis B viral dynamics: a caputo derivative-based approach using artificial neural networks.
Scientific reports
Sep 19, 2024
A fractional model for the kinetics of hepatitis B transmission was developed. The hepatitis B virus significantly affects the world's economic and health systems. Acute and chronic carrier phases play a crucial part in the spread of the HBV infectio...
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