AIMC Topic: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Decoding the diagnostic biomarkers of mitochondrial dysfunction related gene variants in pediatric T cell acute lymphoblastic leukemia.

Scientific reports Jul 1, 2025
Mitochondrial dysfunction is crucial in the pathogenesis and drug resistance of pediatric T-cell acute lymphoblastic leukemia (T-ALL), a malignant hematological disorder with unrestrained proliferation of immature T-cells. Therefore, the primary obje...
Humans Female Biomarkers, Tumor Male Gene Expression Profiling Adolescent Child, Preschool Child Gene Regulatory Networks RNA, Messenger MicroRNAs Mitochondria Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Gene Expression Regulation, Leukemic
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DARDN: A Deep-Learning Approach for CTCF Binding Sequence Classification and Oncogenic Regulatory Feature Discovery.

Genes Jan 23, 2024
Characterization of gene regulatory mechanisms in cancer is a key task in cancer genomics. CCCTC-binding factor (CTCF), a DNA binding protein, exhibits specific binding patterns in the genome of cancer cells and has a non-canonical function to facili...
Humans Deep Learning Transcription Factors DNA Precursor T-Cell Lymphoblastic Leukemia-Lymphoma CCCTC-Binding Factor
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CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia.

Cancer letters May 31, 2022
T cell acute lymphoblastic leukemia (T-ALL) is invasive and heterogeneous, and existing therapies are sometimes unsuccessful. Chimeric antigen receptor (CAR) T cell therapy is a breakthrough tumor treatment method, particularly for B cell acute lymph...
Humans Animals Receptors, Chimeric Antigen T-Lymphocytes Cell Line, Tumor Receptors, Antigen, T-Cell Mice Basigin Immunotherapy, Adoptive Mice, Inbred NOD Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
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