International journal of data mining and bioinformatics
26529910
High-dimensional data and a large number of redundancy features in bioinformatics research have created an urgent need for feature selection. In this paper, a novel random forests-based feature selection method is proposed that adopts the idea of str...
We present a new genetic filter to identify a predictive gene subset for cancer-type classification on gene expression profiles. This approach pursues to not only maximize correlation between selected genes and cancer types but also minimize inter-co...
For cancer classification problems based on gene expression, the data usually has only a few dozen sizes but has thousands to tens of thousands of genes which could contain a large number of irrelevant genes. A robust feature selection algorithm is r...
MOTIVATION: Learning the joint distributions of measurements, and in particular identification of an appropriate low-dimensional manifold, has been found to be a powerful ingredient of deep leaning approaches. Yet, such approaches have hardly been ap...
The role of three-dimensional genome organization as a critical regulator of gene expression has become increasingly clear over the last decade. Most of our understanding of this association comes from the study of long range chromatin interaction ma...
Aging is a multifactorial process that involves numerous genetic changes, so identifying anti-aging agents is quite challenging. Age-associated genetic factors must be better understood to search appropriately for anti-aging agents. We utilized an ag...
Although genomic alterations drive the pathogenesis of acute myeloid leukemia (AML), traditional classifications are largely based on morphology, and prototypic genetic founder lesions define only a small proportion of AML patients. The historical su...
Biochimica et biophysica acta. Gene regulatory mechanisms
39366464
Acute Myeloid Leukaemia (AML) is characterized by uncontrolled growth of immature myeloid cells, disrupting normal blood production. Treatment typically involves chemotherapy, targeted therapy, and stem cell transplantation but many patients develop ...