MOTIVATION: While multi-channel fluorescence microscopy is a vital imaging method in biological studies, the number of channels that can be imaged simultaneously is limited by technical and hardware limitations such as emission spectra cross-talk. On...
STUDY QUESTION: What is the accuracy and agreement of embryologists when assessing the implantation probability of blastocysts using time-lapse imaging (TLI), and can it be improved with a data-driven algorithm?
MOTIVATION: Estimating the effects of interventions on patient outcome is one of the key aspects of personalized medicine. Their inference is often challenged by the fact that the training data comprises only the outcome for the administered treatmen...
Mathematical biosciences and engineering : MBE
May 20, 2022
With the development of the field of survival analysis, statistical inference of right-censored data is of great importance for the study of medical diagnosis. In this study, a right-censored data survival prediction model based on an improved compos...
Animals make efficient probabilistic inferences based on uncertain and noisy information from the outside environment. It is known that probabilistic population codes, which have been proposed as a neural basis for encoding probability distributions,...
A basket trial in oncology encompasses multiple "baskets" that simultaneously assess one treatment in multiple cancer types or subtypes. It is well-recognized that hierarchical modeling methods, which adaptively borrow strength across baskets, can im...
A quantitative evaluation of the contribution of individual units in producing the collective behavior of a complex network can allow us to understand the potential damage to the structure integrity due to the failure of local nodes. Given a time ser...
Supervised learning corresponds to minimizing a loss or cost function expressing the differences between model predictions yn and the target values tn given by the training data. In neural networks, this means backpropagating error signals through th...
Proceedings of the National Academy of Sciences of the United States of America
Jul 13, 2021
Forward genetic studies use meiotic mapping to adduce evidence that a particular mutation, normally induced by a germline mutagen, is causative of a particular phenotype. Particularly in small pedigrees, cosegregation of multiple mutations, occasiona...
Predicting and understanding how people make decisions has been a long-standing goal in many fields, with quantitative models of human decision-making informing research in both the social sciences and engineering. We show how progress toward this go...