Proceedings of the National Academy of Sciences of the United States of America
Mar 7, 2024
Proteins are a diverse class of biomolecules responsible for wide-ranging cellular functions, from catalyzing reactions to recognizing pathogens. The ability to evolve proteins rapidly and inexpensively toward improved properties is a common objectiv...
Cell systems
Feb 9, 2024
A strategy to obtain the greatest number of best-performing variants with least amount of experimental effort over the vast combinatorial mutational landscape would have enormous utility in boosting resource producibility for protein engineering. Tow...
Molecular biotechnology
Feb 3, 2024
Synthetic antibodies (Abs) represent a category of engineered proteins meticulously crafted to replicate the functions of their natural counterparts. Such Abs are generated in vitro, enabling advanced molecular alterations associated with antigen rec...
Science (New York, N.Y.)
Jan 25, 2024
The power and accuracy of computational protein design have been increasing rapidly with the incorporation of artificial intelligence (AI) approaches. This promises to transform biotechnology, enabling advances across sustainability and medicine. DNA...
Chembiochem : a European journal of chemical biology
Nov 27, 2023
Poly (ethylene terephthalate) (PET) is one of the most commonly used plastics in daily life and various industries. Enzymatic depolymerization and recycling of post-consumer PET (pc-PET) provides a promising strategy for the sustainable circular econ...
Applied microbiology and biotechnology
Aug 24, 2023
Enzymes have promising applications in chemicals, food, pharmaceuticals, and other variety products because of their high efficiency, specificity, and environmentally friendly properties. However, due to the complexity of raw materials, pH, temperatu...
Metabolic engineering
Jun 8, 2023
Retro-biosynthetic approaches have made significant advances in predicting synthesis routes of target biofuel, bio-renewable or bio-active molecules. The use of only cataloged enzymatic activities limits the discovery of new production routes. Recent...
Nature communications
May 6, 2023
Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explore the au...
Science (New York, N.Y.)
Apr 20, 2023
As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approa...
Mathematical biosciences and engineering : MBE
Dec 21, 2022
Protein engineering uses de novo protein design technology to change the protein gene sequence, and then improve the physical and chemical properties of proteins. These newly generated proteins will meet the needs of research better in properties and...