AIMC Topic: Mutagenesis, Insertional
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Landscape of essential growth and fluconazole-resistance genes in the human fungal pathogen Cryptococcus neoformans.
PLoS biology
May 22, 2025
Fungi can cause devastating invasive infections, typically in immunocompromised patients. Treatment is complicated both by the evolutionary similarity between humans and fungi and by the frequent emergence of drug resistance. Studies in fungal pathog...
Characterizing the function of domain linkers in regulating the dynamics of multi-domain fusion proteins by microsecond molecular dynamics simulations and artificial intelligence.
Proteins
Mar 27, 2021
Multi-domain proteins are not only formed through natural evolution but can also be generated by recombinant DNA technology. Because many fusion proteins can enhance the selectivity of cell targeting, these artificially produced molecules, called mul...
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia.
Nature neuroscience
Jan 11, 2021
Retrotransposons can cause somatic genome variation in the human nervous system, which is hypothesized to have relevance to brain development and neuropsychiatric disease. However, the detection of individual somatic mobile element insertions present...
Neuroglia
Cation Transport Proteins
Retroelements
Mutagenesis, Insertional
Embryonic Development
Genome
HeLa Cells
Adaptor Proteins, Signal Transducing
Adult
Neurons
Long Interspersed Nucleotide Elements
Humans
Machine Learning
Schizophrenia
Pregnancy
High-Throughput Nucleotide Sequencing
Female
Mental Disorders
Unsupervised Learning Approach for Comparing Multiple Transposon Insertion Sequencing Studies.
mSphere
Feb 20, 2019
Transposon insertion sequencing (TIS) is a widely used technique for conducting genome-scale forward genetic screens in bacteria. However, few methods enable comparison of TIS data across multiple replicates of a screen or across independent screens,...
Gene Essentiality Analyzed by Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of .
mBio
Oct 30, 2018
Knowing the full set of essential genes for a given organism provides important information about ways to promote, and to limit, its growth and survival. For many non-model organisms, the lack of a stable haploid state and low transformation efficien...
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