AI Medical Compendium Topic

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Proteogenomics

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Deep learning integrates histopathology and proteogenomics at a pan-cancer level.

Cell reports. Medicine
We introduce a pioneering approach that integrates pathology imaging with transcriptomics and proteomics to identify predictive histology features associated with critical clinical outcomes in cancer. We utilize 2,755 H&E-stained histopathological sl...

Mapping the functional network of human cancer through machine learning and pan-cancer proteogenomics.

Nature cancer
Large-scale omics profiling has uncovered a vast array of somatic mutations and cancer-associated proteins, posing substantial challenges for their functional interpretation. Here we present a network-based approach centered on FunMap, a pan-cancer f...