AIMC Topic: Proteogenomics

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Mapping the functional network of human cancer through machine learning and pan-cancer proteogenomics.

Nature cancer Dec 11, 2024
Large-scale omics profiling has uncovered a vast array of somatic mutations and cancer-associated proteins, posing substantial challenges for their functional interpretation. Here we present a network-based approach centered on FunMap, a pan-cancer f...
Humans Neural Networks, Computer Machine Learning Neoplasms Protein Interaction Maps Gene Regulatory Networks Proteomics Mutation Proteogenomics
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Deep learning integrates histopathology and proteogenomics at a pan-cancer level.

Cell reports. Medicine Aug 14, 2023
We introduce a pioneering approach that integrates pathology imaging with transcriptomics and proteomics to identify predictive histology features associated with critical clinical outcomes in cancer. We utilize 2,755 H&E-stained histopathological sl...
Humans Machine Learning Neoplasms Deep Learning Proteomics Proteogenomics
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The melanoma MEGA-study: Integrating proteogenomics, digital pathology, and AI-analytics for precision oncology.

Journal of proteomics Aug 15, 2025
Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clin...
Humans Machine Learning Precision Medicine Female Melanoma Skin Neoplasms Tumor Microenvironment Male Proteogenomics
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