AIMC Topic: Rats, Inbred SHR

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Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism.

Alcoholism, clinical and experimental research Jun 13, 2018
BACKGROUND: A statistical pipeline was developed and used for determining candidate genes and candidate gene coexpression networks involved in 2 alcohol (i.e., ethanol [EtOH]) metabolism phenotypes, namely alcohol clearance and acetate area under the...
Animals Male Systems Biology Rats Ethanol Liver Unsupervised Machine Learning Alcohol Drinking Metabolic Clearance Rate Rats, Inbred BN Rats, Transgenic Multifactorial Inheritance Rats, Inbred SHR
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Microarray expression profiling and gene ontology analysis of long non-coding RNAs in spontaneously hypertensive rats and their potential roles in the pathogenesis of hypertension.

Molecular medicine reports Nov 11, 2015
Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential...
Reproducibility of Results Animals Gene Expression Profiling Real-Time Polymerase Chain Reaction Hypertension RNA, Long Noncoding Gene Expression Regulation Down-Regulation Gene Ontology Oligonucleotide Array Sequence Analysis Rats, Inbred SHR Rats, Inbred WKY
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