AIMC Topic: Receptors, Antigen, T-Cell, alpha-beta

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Machine learning reveals distinct T-cell receptor clusters in plasma cell dyscrasias compared to healthy controls.

PloS one Oct 27, 2025
T-cell receptor (TCR) repertoire diversity has been implicated in the progression and prognosis of multiple myeloma (MM). This study aimed to evaluate the association between T-cell clonality, immune response, and clinical outcomes in patients with p...
Humans Machine Learning Female Aged Aged, 80 and over Male Middle Aged Case-Control Studies Receptors, Antigen, T-Cell High-Throughput Nucleotide Sequencing Multiple Myeloma Receptors, Antigen, T-Cell, alpha-beta Monoclonal Gammopathy of Undetermined Significance Paraproteinemias
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Single T Cell Sequencing Demonstrates the Functional Role of TCR Pairing in Cell Lineage and Antigen Specificity.

Frontiers in immunology Jul 31, 2019
Although structural studies of individual T cell receptors (TCRs) have revealed important roles for both the α and β chain in directing MHC and antigen recognition, repertoire-level immunogenomic analyses have historically examined the β chain alone....
Humans Machine Learning CD8-Positive T-Lymphocytes CD4-Positive T-Lymphocytes Antigens Sequence Analysis, Protein Complementarity Determining Regions Receptors, Antigen, T-Cell, alpha-beta
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Feature selection using a one dimensional naïve Bayes' classifier increases the accuracy of support vector machine classification of CDR3 repertoires.

Bioinformatics (Oxford, England) Apr 1, 2017
MOTIVATION: Somatic DNA recombination, the hallmark of vertebrate adaptive immunity, has the potential to generate a vast diversity of antigen receptor sequences. How this diversity captures antigen specificity remains incompletely understood. In thi...
Humans Animals Support Vector Machine Databases, Genetic Mice, Inbred C57BL Bayes Theorem Amino Acids CD4-Positive T-Lymphocytes Complementarity Determining Regions Receptors, Antigen, T-Cell, alpha-beta
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