AIMC Topic: Receptors, Chemokine

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Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network.

Cell Apr 23, 2025
In humans, selective and promiscuous interactions between 46 secreted chemokine ligands and 23 cell surface chemokine receptors of the G-protein-coupled receptor (GPCR) family form a complex network to coordinate cell migration. While chemokines and ...
Humans Protein Binding Receptors, G-Protein-Coupled Models, Molecular Amino Acid Sequence Ligands Chemokines Receptors, Chemokine
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Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients.

International journal of molecular sciences Oct 12, 2021
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult...
Humans Machine Learning Phenotype Female Aged Adult Middle Aged ROC Curve Monocytes Psoriasis Diagnosis, Differential Arthritis, Psoriatic Area Under Curve Discriminant Analysis T-Lymphocytes, Regulatory T-Lymphocyte Subsets B-Lymphocyte Subsets Receptors, Chemokine
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