AIMC Topic: T-Lymphocyte Subsets

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The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model.

Autoimmunity Nov 19, 2025
Systemic lupus erythematosus (SLE), characterized by immune dysregulation, urgently requires improved diagnostic tools and mechanistic insights. The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell transcripto...
Humans Machine Learning Biomarkers Transcriptome Single-Cell Analysis Lupus Erythematosus, Systemic T-Lymphocyte Subsets Interferon Regulatory Factor-1 Female Adult Male Gene Expression Profiling
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Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients.

International journal of molecular sciences Oct 12, 2021
Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult...
Middle Aged ROC Curve Monocytes Psoriasis Phenotype Female Aged Adult T-Lymphocytes, Regulatory T-Lymphocyte Subsets B-Lymphocyte Subsets Receptors, Chemokine Diagnosis, Differential Arthritis, Psoriatic Area Under Curve Discriminant Analysis Humans Machine Learning
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Combination Strategies for Immune-Checkpoint Blockade and Response Prediction by Artificial Intelligence.

International journal of molecular sciences Apr 19, 2020
The therapeutic concept of unleashing a pre-existing immune response against the tumor by the application of immune-checkpoint inhibitors (ICI) has resulted in long-term survival in advanced cancer patient subgroups. However, the majority of patients...
Immunotherapy Cancer Vaccines Treatment Outcome Antineoplastic Agents, Immunological T-Lymphocyte Subsets Biomarkers, Tumor Combined Modality Therapy Animals Molecular Targeted Therapy Neoplasms Immune Checkpoint Inhibitors Humans Artificial Intelligence
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SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses.

Journal of immunology (Baltimore, Md. : 1950) Jun 14, 2019
Machine learning holds considerable promise for understanding complex biological processes such as vaccine responses. Capturing interindividual variability is essential to increase the statistical power necessary for building more accurate predictive...
Datasets as Topic T-Lymphocyte Subsets Male Algorithms Adolescent Influenza, Human Female Child Data Mining Young Adult Vaccination CD8-Positive T-Lymphocytes Humans Influenza Vaccines Adult CD4-Positive T-Lymphocytes Machine Learning
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Indoleamine 2,3-Dioxygenase (IDO) Enzyme Links Innate Immunity and Altered T-Cell Differentiation in Non-ST Segment Elevation Acute Coronary Syndrome.

International journal of molecular sciences Dec 26, 2017
Atherosclerosis is a chronic inflammatory disease characterized by a complex interplay between innate and adaptive immunity. Dendritic cells (DCs) play a key role in T-cell activation and regulation by promoting a tolerogenic environment through the ...
T-Lymphocyte Subsets Female Indoleamine-Pyrrole 2,3,-Dioxygenase Aged Aged, 80 and over Male Monocytes Adult Humans Middle Aged Non-ST Elevated Myocardial Infarction Immunity, Innate Cells, Cultured Dendritic Cells Cell Differentiation Lymphocyte Activation Acute Coronary Syndrome
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Sensitive detection of rare disease-associated cell subsets via representation learning.

Nature communications Apr 6, 2017
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...
Signal Transduction Acquired Immunodeficiency Syndrome Cytomegalovirus Infections Supervised Machine Learning T-Lymphocyte Subsets Rare Diseases Neoplasm, Residual Survival Analysis Killer Cells, Natural Cytokines Prognosis Leukemia Single-Cell Analysis Humans Immunologic Memory Monocytes Neural Networks, Computer
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T-cell Subset Features and Distributions Evolve across the Colorectal Precancer-Cancer Spectrum.

Cancer immunology research Jan 8, 2026
The immune microenvironment is a crucial component of colorectal carcinoma that has been well characterized, but much less is known about the immune microenvironment of colorectal carcinoma precursors. We hypothesized that T-cell infiltrates might di...
Precancerous Conditions Male Middle Aged Lymphocytes, Tumor-Infiltrating T-Lymphocyte Subsets Aged Prospective Studies Humans Colorectal Neoplasms Female Tumor Microenvironment
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Associations between Calcium Intake and T-cell Infiltration in Colorectal Tumors.

Cancer prevention research (Philadelphia, Pa.) Sep 2, 2025
UNLABELLED: Higher T-cell infiltration in colorectal tumors has been associated with better prognosis. Evidence indicates that calcium signaling is essential for T-cell functioning. However, as it is unknown whether calcium intake influences T-cell i...
Humans Lymphocytes, Tumor-Infiltrating T-Lymphocyte Subsets Calcium, Dietary Tumor Microenvironment Prognosis Male Female Middle Aged Aged Cohort Studies Colorectal Neoplasms
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Estimating Normal Values of Rare T-Lymphocyte Populations in Peripheral Blood of Healthy Cuban Adults.

MEDICC review Oct 1, 2018
INTRODUCTION Flow cytometry allows immunophenotypic characterization of important lymphocyte subpopulations for diagnosis of diseases such as cancer, autoimmune diseases, immunodeficiencies and some infections. Normal values of rare lymphoid cells in...
Lymphocyte Count Adolescent Sex Factors Humans Age Factors Young Adult T-Lymphocyte Subsets CD4-CD8 Ratio Female CD4 Lymphocyte Count Adult Cuba Aged Male Reference Values Killer Cells, Natural Aged, 80 and over Middle Aged
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